the objective of this work was to develop bioadhesive topical gel of aceclofenac with the help of response-surface approach. experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of poloxamer 407 (pl-407 = x1) and hydroxypropylmethyl cellulose k100 m (hpmc = x2)] on the bioadhesive character of gel, rheological property o...

Fitting response surface models is usually carried out using statistical packages to solve complicated equations in order to produce the estimates of the model coefficients. This paper proposes a new procedure for fitting response surface models to mixed two-level and four-level factorial designs. New and easier formulae are suggested to calculate the linear, quadratic and the interaction coeff...

difference aspects of multinomial statistical modelings and its classifications has been studied so far. in these type of problems y is the qualitative random variable with t possible states which are considered as classifications. the goal is prediction of y based on a random vector x ? ir^m. many methods for analyzing these problems were considered. one of the modern and general method of cla...

BACKGROUND Anesthetic drug interactions traditionally have been characterized using isobolographic analysis or multiple logistic regression. Both approaches have significant limitations. The authors propose a model based on response-surface methodology. This model can characterize the entire dose-response relation between combinations of anesthetic drugs and is mathematically consistent with mo...

this study investigates the degradation of sodium dodecylbenzenesulfonate (sdbs) in aqueous solution by the fenton-like oxidation process. the effects of different parameters such as concentrations of ferric chloride and hydrogen peroxide, ph and reaction time on the sdbs removal and chemical oxygen demand (cod) reduction were evaluated. response surface methodology (rsm) with central composite...

background and objective: lactobacillus plantarum is one of the probiotics species used in functional food products. these bacteria or their purified bacteriocins are used as biological preservatives in the food industry. the first step in production of an array of probiotic products is optimizing production in fermentors. this study aimed to examine factors affecting the in vitro growth optimi...

the optimization of process conditions for the degradation of acid blue 193 by uv/peroxydisulfate was investigated using response surface methodology (rsm). the effects of four parameters namely initial k2s2o8 concentration, uv irradiation, temperature, and initial dye concentration on two process responses, color removal and the rate constants of the first-order kinetic equations, were investi...

biodegradation of phenanthrene (phe) was studied in aqueous culture to demonstrate the potential of the mixed culture in degrading high concentration of phe. the experiments were conducted to monitor biodegradation of phenanthrene for duration of 6 days. biodegradation of phe was successfully achieved in low and middle concentration by the isolated mixed culture. a full factorial central compos...