A biological marker (biomarker) is a physical sign or laboratory measurement that can serve as an indicator of biological or pathophysiological processes or as a response to a therapeutic intervention. An applicable biomarker possesses the characteristics of clinical relevance (sensitivity and specificity for the disease) and is responsive to treatment effects, in combination with simplicity, r...

iomarkers are measurable cells, proteins, and/or metabolic yproducts that represent, either directly or indirectly, one or ore processes in a defined biological system or disease tate (2). Because biomarkers reflect health and disease ccording to genetic makeup, gene–gene interactions, gene– nvironmental interactions, and a dynamic interface beween genotype–phenotype relationships (3), one coul...

There has been a surge of interest in biomarkers that can rapidly predict or assess response to psychiatric treatment, as the current standard practice of extended therapeutic trials is often dissatisfying to both clinicians and patients. Electroencephalographic (EEG) biomarkers in particular have been proposed as an inexpensive yet rapid way of determining whether a patient is responding to an...

We read with interest the proteomic study by Collinson and colleagues (1), proposing a biomarker signature with promising ability in predicting benefit from the addition of bevacizumab to standard chemotherapy in epithelial ovarian cancer (EOC). The identification of predictors of benefit from bevacizumab is one of the most pressing priority in medical oncology, as indications for its use have ...