Maintaining synaptic integrity and function depends on the continuous removal and degradation of aged or damaged proteins. Synaptic protein degradation has received considerable attention in the context of synaptic plasticity and growing interest in relation to neurodegenerative and other disorders. Conversely, less attention has been given to constitutive, ongoing synaptic protein degradation ...

purpose: to report two sisters with congenital myasthenic syndrome (cms) masquerading as myasthenia gravis. patients and findings: two six and seven years old sisters presented with variable strabismus, ptosis, and fatigue. all symptoms were aggravated with exercise and improved with rest. intramuscular prostigmin injection decreased their symptoms. a diagnosis of cms was made according to earl...

inguinal mass is a common clinical finding or even symptom in childhood while the most common diagnosis is inguinal hernia that may proceed with prompt surgical but there are a vast variety of different entities that may manifest as an inguinal mass and in some instances, surgical approach is not indicated or may need further preoperative assessments to determine a correct therapeutic plan. in ...

the hematological malignancies associated with nephrotic syndrome are mainly hodgkin’s and non-hodgkin’s lymphomas and chronic lymphocytic leukemia. acute myelogenous leukemia (aml) has rarely been described in associated with nephritic syndrome. we report a rare case of acute myelogenous leukemia who presented with nephrotic syndrome. a previously healthy 62-year-old man was admitted in nephro...

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intraosseous movement of an unerupted tooth across the midline of the jaw is known as dental transmigration. this infrequent event is mostly found in the mandibular canines. there are four new cases of mandibular canine transmigration presented here. the literature on this anomalous phenomenon is also reviewed.

background: neurobrucellosis is a rare complication of brucellosis. acute meningitis and encephalitis are the most common clinical manifestations; however, symptoms of these two conditions may be subacute and diagnosis requires a high index of suspicion in patients from endemic areas. diagnosis is often based on neurological symptoms, serology, and suggestive brain imaging because cerebrospinal...

neuroblastoma is the most common extracranial solid tumor in childhood. in different classification of neuroblastomas, a subset of undifferentiated or poorly differentiated tumors with bizarre histological features has been mentioned. a 3-year-old girl presented with abdominal pain. her haematological and biochemical parameters were normal except her urinary vanelylmandelic acid level was elevat...

congenital or neonatal rhabdomyosarcoma is a rare entity, usually presenting as masses in the head and neck region as well as genitourinary tract. the embryonal variant is the most common type occurring in infancy. this is a case of congenital rhabdomyosarcoma with a huge forearm mass, with metastatic discrete nodules in the soft tissues of the neck and scapular region, resembling a ‘blueberry ...