Acute renal failure is present in 1 to 5 percent of patients at hospital admission and affects 15 to 20 percent of patients in intensive care units [2]. In a study in Madrid, pre-renal type of acute renal failure accounted for 21% of cases, post-renal type constituted 10% of cases and intrinsic-type accounted for 69% of cases [2]. Renal replacement therapy is the life saving procedure for patie...

The management of patients with concomitant xenobiotic toxicity and multisystem trauma can be complex. While hemodialysis is generally the modality of choice for extracorporeal elimination of salicylates, the potential for large volume shifts and hypotension may pose a risk in patients with traumatic brain injury. An alternative therapy to hemodialysis is continuous renal replacement therapy, w...

Acute renal failure is present in 1 to 5 percent of patients at hospital admission and affects 15 to 20 percent of patients in intensive care units [2]. In a study in Madrid, pre-renal type of acute renal failure accounted for 21% of cases, post-renal type constituted 10% of cases and intrinsic-type accounted for 69% of cases [2]. Renal replacement therapy is the life saving procedure for patie...

BACKGROUND AND OBJECTIVES Current recommendations for piperacillin-tazobactam dosing in patients receiving continuous renal replacement therapy originate from studies with relatively few patients and lower continuous renal replacement therapy doses than commonly used today. This study measured the pharmacokinetic and pharmacodynamic characteristics of piperacillin-tazobactam in patients treated...

Acute renal failure (ARF) is a common condition in hospitalized patients. The aetiology and physiological characteristics differ from those of chronic renal failure (CRF) and both conditions should be approached differently. At present, the approach to the management of ARF is very heterogeneous. Attempts have therefore been made to improve consensus and to standardize treatment in the Acute Di...

OBJECTIVE To evaluate the prognostic value of platelet counts in acute kidney injury patients requiring renal replacement therapy. METHODS This prospective cohort study was performed in three tertiary-care hospitals. Platelet counts were obtained upon admission to the intensive care unit and during the first week of renal replacement therapy on days 1, 3, 5 and 7. The outcome of interest was ...