BACKGROUND Blood Oxygen Level Dependent (BOLD) magnetic resonance (MR) is a novel imaging tool that detects changes in tissue oxygenation. Increases in renal oxygenation in response to a standard 20 mg intravenous furosemide stimulus have been evaluated to assess kidney viability in patients with renal artery stenosis (RAS). The effect of prior exposure to furosemide on the ability of BOLD MR t...

This review of adaptive changes in renal structure and function in subjects with reduced renal mass has two primary goals. One is to provide a description of the remarkable compensatory increases in glomerular filtration rate (GFR), and renal blood flow, at the level of individual nephrons, and the alterations in water and electrolyte transport by tubular epithelium. These processes preserve fl...

In order to study the distribution of blood flow in diseased human kidneys, Xe133 washout curves were obtained from 34 patients with chronic renal disease or hypertension. The curves recorded for over 45 min. were resolved into 4 components, while the curves recorded for 30 min. showed 3 components. The values of components I, II and III in the 30 min. record coincided with those of the compone...

It is generally assumed that renal blood flow is symmetric in the absence of renal artery stenosis. The aim of the present study was to evaluate whether this is really the case. From a group of consecutive hypertensive patients who had undergone renal angiography, we selected those with patent renal arteries. In all of them selective renal blood flow (RBF) measurements (133Xenon washout techniq...

primary sarcomas of the kidney are exceptional. among renal sarcomas, leiomyosarcoma is the most common histologic subtype amounting to 50-60% of all cases. the tumor usually arises from either the renal capsule or smooth muscle tissue in the renal pelvic wall. in this paper, we report a patient with leiomyosarcoma of the kidney presented with non-specific abdominal pain and a palpable mass. hi...

AIMS To evaluate renal morphology, prevalence of urinary stone disease, renal perfusion and resistance to renal blood flow in patients with ankylosing spondylitis(AS). MATERIAL AND METHODS Thirty-eight patients diagnosed with AS and with normal basal renal functions, together with 38 healthy individuals matched in terms of age, sex, blood lipid profile and body mass index, were included. Tota...

Hypertension-induced renal damage is mediated by increased glomerular pressure and flow. These alterations have been evaluated by the renal response to protein or amino acids. To test this assumption, we studied glomerular hemodynamic responses to glycine infusion in rats with reduced renal mass, with and without Goldblatt hypertension. The left kidney was ablated by two thirds in 12 rats, and ...

This paper compares three methods for estimating renal function, as tested in rats. Acute renal failure (ARF) was induced via a 60-min bilateral renal artery clamp in 8 Sprague-Dawley rats and renal function was monitored for 1 week post-surgery. A two-compartment model was developed for estimating glomerular filtration via a bolus injection of a radio-labelled inulin tracer, and was compared w...

Selective cyclooxygenase (COX)-2 inhibitors that are in widespread clinical use were developed to avoid side effects of conventional NSAIDs, including gastrointestinal and renal toxicity. However, COX-2 is constitutively expressed in the kidney and is highly regulated in response to alterations in intravascular volume. COX-2 metabolites have been implicated in maintenance of renal blood flow, m...

Renal cell carcinoma is an uncommon tumor in pediatric population.It is important for the clinicians to know its diagnosis as the management of renal cell carcinoma RCC is different from Wilms Tumor which is the most common tumor encountered in children .The management is surgical resection with no proven role for chemo or radiotherapy so far. Here, we present a case of seven-year-old male chil...