The Wright–Fisher equation, which was introduced as a model to study demography in the presence of diffusion, has had a renaissance as a model for the migration of alleles in the genome. Our goal in this paper is to give a careful analysis of the fundamental solution to the Wright–Fisher equation, with particular emphasis on its behavior for a short time near the boundary.

In the past 15 years, the organisation of hospital care has been transformed in both the United States and United Kingdom. In the US, the traditional model—in which primary care physicians came to the hospital to oversee inpatient care—was supplanted by one in which a hospital based generalist physician, the hospitalist, assumed this role. In UK hospitals, acute physicians have taken over from ...

Factorial models and analysis of variance have been a central pillar of statistical thinking and practice for at least 70 years, so the opportunity to revisit these topics to look for signs of new life is welcome. Given its lengthy history, Anova is an unpromising area for new development, but recent advances in computational techniques have altered the outlook regarding spatial factors, and co...

Enlargements of the thyroid gland known as goiters appear in artworks and artifacts of many cultures. They are represented in sculptures, bas-reliefs, masks, waxes, mosaics, bronzes, stained glass windows, paintings and drawings of the last two millennia. These are described in several monographs and in Merke's scholarly History and Iconography of Endemic Goitre and Cretinism (Barbieri 1993, Gi...

The waterfall model of conventional software management, which is still prevalent in many mature software organizations, has served its purpose. The ever-increasing market demands on software development performance continue. The increasing breadth of Internet applications has further accelerated the transition to a more modern management process known as spiral, incremental, evolutionary, or i...

neutrum, and ut nunc and simpliciter. The more technical chapters devoted to explaining these theoretical concepts are nicely balanced by an excellent introductory chapter on Galenic medicine in the Renaissance, and a fascinating closing chapter on Renaissance discussions of whether neutral bodies really do exist in nature and whether ageing bodies and convalescing bodies provide practical exam...

ARHA110 Introduction to Western Art: Renaissance to Modern This course surveys the development of Western art from the Renaissance through the modern period. We will examine art's changing status within specific social and artistic contexts: from the Church and court of the Renaissance, through the formation of art academies in the late 16th century, to the development of an increasingly indivi...

The article examines the truthfulness of historical accounts claiming that Renaissance Duke Federico of Montefeltro (1422-1482) suffered from gout. By direct paleopathological assessment of the skeletal remains and by the philological investigation of historical and documental sources, primarily a 1461 handwritten letter by the Duke himself to his personal physician, a description of the sympto...