Bijma et al. (2007a,b) presented a quantitative genetic theory of multilevel selection and showed how to estimate the relevant parameters using standard restricted maximum-likelihood (REML) methodology. Extending their results we develop a wider class of models that provide a more realistic framework for capturing the effects of interacting individuals. These models also make use of standard RE...

ABSTRACT The SAS ® procedure MIXED provides a single tool for analyzing a large array of models used in statistics, especially experimental design, through the use of REML estimation. A strategy for identifying mixed models is followed by a description of REML estimation along with a simple example that illustrates its advantages. A comparison of some of the available tests for variance compone...

AIM Intravascular ultrasound (IVUS) is a useful modality for visualizing atherosclerotic lesions in coronary arteries, not only for the degree of arterial luminal stenosis but also for the plaque composition within the vessel walls. We aimed to determine the relationship between the clinical parameters and coronary plaque characteristics evaluated by IVUS in patients with stable angina under me...

This paper considers double generalized linear models, which allow the mean and dispersion to be modelled simultaneously in a generalized linear model context. Estimation of the dispersion parameters is based on a χ1 approximation to the unit deviances, and the accuracy of the saddle-point approximation which underlies this is discussed. Approximate REML methods are developed for estimation of ...

Crossed random effects models can simultaneously take into account both fixed and of the subjects stimuli when observations are nested within combinations stimuli. Unfortunately, maximum likelihood estimation (MLE) restricted (REML) often encounter convergence problems, which in turn lead researchers to fit simpler that yield invalid statistical inferences. On other hand, if structure is too si...

IMPORTANCE Narcolepsy, a disorder associated with HLA-DQB1*06:02 and caused by hypocretin (orexin) deficiency, is diagnosed using the Multiple Sleep Latency Test (MSLT) following nocturnal polysomnography (NPSG). In many patients, a short rapid eye movement sleep latency (REML) during the NPSG is also observed but not used diagnostically. OBJECTIVE To determine diagnostic accuracy and clinica...

Restricted Maximum Likelihood (REML) is the most recommended approach for fitting a Linear Mixed Model (LMM) nowadays. Yet, as ML, REML suffers drawback that it performs such by assuming normality both random effects and residual errors, dubious assumption many real data sets. Now, there have been several attempts at trying to justify use of likelihood equations outside Gaussian world, with var...

The purpose of this study is to present the general concept Bayesian analysis and Markov chain Monte Carlo (MCMC) algorithm make some numerical comparisons with frequentist analyses. A factorial randomized complete-block (RCB) experiment used analyze cowpea data set that has four separate single-column replicates, each containing 9 combinations 3 varieties spacings. Response yield hay. Point es...