Abstract: Introduction: Traumatic Brain Injury (TBI) conditions require immediate treatment such as the administration of analgesics and sedation, including remifentanil. TBI will affect levels several inflammatory apoptotic proteins MAC, Bax, Bcl-2. Remifentanil with its high affinity to μ-receptors is thought these has neuroprotective properties prevent secondary brain injury. Objectives: Thi...

Opioids have been considered for their hemodynamic stability. Remifentanil is an opioid analgesic with rapid metabolism and fast primary effect and recovery. In this paper, a very rare effect of using remifentanil along with propofol was presented. An 84-year-old male patient with severe aortic stenosis underwent general anesthesia. In order to induce anesthesia and maintain it, fentanyl, pancu...

Background: Early warning of potential damage to spinal cord during major spinal surgery is highly desirable to prevent post-operative neurological deficits. Wake-up test is a simple, safe and reliable method of recognition of such a complication, and has been extensively used in many spinal surgical units. The present study is evaluating the remifentanil, propofol versus alfentanil, propofol a...

Johanna Savilampi (2015): Effects of remifentanil on esophageal sphincters and swallowing function, Örebro Studies in Medicine 119. Pulmonary complications like pneumonia are common perioperatively, and one potentially important cause is thought to be silent aspiration. There are several levels of defence against pulmonary aspiration that can be affected by drugs in anaesthesia. Competence of e...

BACKGROUND Experimental and clinical studies have suggested that remifentanil probably causes acute tolerance or postinfusion hyperalgesia. This study was designed to confirm whether remifentanil given during propofol anesthesia induced postoperative pain sensitization, and we wanted to investigate whether pregabalin could prevent this pronociceptive effect. METHODS Sixty patients who were sc...

BACKGROUND Propofol and remifentanil can be combined to deliver total intravenous anesthesia (TIVA). Propofol and remifentanil are sometimes mixed in the same syringe. Since remifentanil is a solution and propofol is an emulsion, we hypothesized that they would separate over time when mixed in the same syringe. METHODS Nine 60-ml polypropylene syringes were prepared as follows: Group A: 1.25 ...

BACKGROUND Endotracheal intubation induces clinically adverse cardiovascular changes. Various pharmacological strategies for controlling these responses have been suggested with opioids being widely administered. In this study, the optimal effect-site concentration (Ce) of remifentanil for minimizing hemodynamic responses to fiberoptic nasotracheal intubation was evaluated. METHODS Thirty pat...