In this study, ionic immobilization of dexamethasone (DEX)-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres was performed on the hydroxyapatite (HAp) scaffold surfaces. It was hypothesized that in vivo bone regeneration could be enhanced with HAp scaffolds containing DEX-loaded PLGA microspheres compared to the use of HAp scaffolds alone. In vitro drug release from the encapsulated micr...

Poly(ester-anhydride) microspheres were prepared using emulsion solvent evaporation technique from two copolymers obtained by polycondensation of sebacic acid (SBA) and oligo(3-allyloxy-1,2-propylene succinate) terminated with carboxyl groups (OSAGE). The SBA content in copolymers was 90 or 70 w/w %, respectively. The size of microspheres obtained was in the range of 2-4 microm (small microsphe...

When gene therapy is performed for the treatment of malignant tumors, gene transfer efficiency and selectivity are highly important. Polymer vehicle microspheres are a novel type of therapy, which have been developed rapidly in recent years and are able to control drug release, prolong the biological half-life of drugs, decrease side effects and achieve targeted delivery. The present study was ...

The current treatment approaches for allergic rhinitis are practiced over decades, but the patient quality of life has not yet changed so much. reasons research gaps in pathophysiology disease, proper management disease. Fexofenadine HCl is a second-generation antihistamine drug which half-life about 14.4 h. It useful common symptoms like sneezing, itchy throat, and red eyes individuals sufferi...

All-trans-retinoic acid (atRA) has been proved to be effective against several malignancies in human clinical trials. However, in many patients who were treated with atRA, the cancer relapsed after a brief remission. One reason for such relapse is that atRA is metabolized by specific P450s that are induced in the liver during prolonged atRA treatments. In order to overcome such a drawback of at...

An increasing number of drugs are needing improved formulations to optimize patient compliance because of their short half-lives in blood. Sustained-release formulations of drugs are often required for long-term efficacy, and microspheres are among the most popular ones. When drugs are encapsulated into microsphere formulations, different methods of preparation need to be used according to spec...

PURPOSE Drug release profiles were established for ibuprofen encapsulated within several types of microspheres and a range of dissolution buffer media to study the effect these variables have in controlling the rate and extent of drug release. METHODS Fatty acid microspheres containing ibuprofen were prepared by a process previously developed and refined to produce microspheres of a known siz...

The aim of the current study was to formulate and optimize the formulation on the basis of in vitro performance of microsphere. A 3(2) full factorial design was employed to study the effect of independent variables, polymer-to-drug ratio (X(1)) and stirring speed (X(2)), on dependent variables, encapsulation efficiency, particle size, and time to 80% drug release. The best batch exhibited a hig...

OIC-A006 (BMPs osteogenesis compounds), can stimulate bone marrow mesenchymal stem cells ALP, OPN, OC, Cbfal expression. To stimulate new bone formation in the body. We postulate different amounts of drug microspheres on the PLGA/β-CPT scaffold can produce the effects on performance and sustained release characteristics. In this paper, through adding different amount of carrier drug microsphere...