نتایج جستجو برای: release floating tablet
تعداد نتایج: 262841 فیلتر نتایج به سال:
Migraine follows circadian rhythm in which headache is more painful at the awakening time. This needs administration of dosage form at night time to release drug after lag period when pain gets worse. Sumatriptan succinate is a drug of choice for migraine. Sumatriptan succinate has bitter taste, low oral bioavailability, and shorter half-life. Present work deals with application of design of ex...
Cefdinir (Cef) is a third-generation cephalosporin antibacterial agent with an extended spectrum and low solubility permeability. In this study, cefdinir was prepared as nanosuspension lyophilized to powder. The further processed develop bilayer tablet. By utilizing the approach, first therapeutic action impacted by immediate part's rapid disintegration prolonged release from floating part achi...
The gastroretentive dosage forms have potential for use as controlled-release drug delivery systems. The use of floating dosage forms is one method to achieve prolonged gastric residence times, providing opportunity for both local and systemic drug action. The present investigation involve the development and in vitro evaluation of the floating matrix tablets, which after oral administration ca...
Objective: The recent study's objective was to optimize and formulate a controlled-release gastro-retentive floating tablet of RG using central composite design, which provides continuous release Repaglinide for up 24 h. Methods: (RG-GRF Tablet) prepared by direct compression method. optimization carried out three-factor three-level Central Composite design. amount Eudragit RSPO (A), HPMC K-100...
Floating multi-layer coated tablets were designed based on gas formation. The system consists of a drug-containing core tablet coated with a protective layer (hydroxypropyl methylcellulose), a gas forming layer (sodium bicarbonate) and a gas-entrapped membrane, respectively. The mechanical properties of acrylic polymers (Eudragit RL 30D, RS 30D, NE 30D) and ethylcellulose were characterized by ...
The aim of the present work was to develop a gastroretentive floating tablet of Atenolol and investigate the effects of both hydrophilic and hydrophobic retardant on in vitro release. Atenolol is an antihypertensive drug with an oral bioavailability of only 50% because of its poor absorption from lower gastrointestinal tract. The floating tablets of Atenolol were prepared to increase the gastri...
A Novel floating controlled release drug delivery system of famotidine was formulated in an effort to increase the gastric retention time of the dosage form and to control drug release. The present work investigates the approach using two different polymers HPMC K100 M and natural polymer Chitosan . A floating drug delivery system (FDDS) was developed using gas-forming agents, like sodium bicar...
The present investigation describes the design and evaluation of monolithic gastro retentive dosage forms of diltiazem. Hydrophilic cellulose derivatives, Sodium alginate, Sodium carboxy methyl cellulose, Polyox, Methocel K100M in combination with Methocel E6LV are used as the rate controlling polymers. Sodium bicarbonate was incorporated as gas generating agent. Tablets were prepared by employ...
Atenolol, an antihypertensive drug, has poor bioavailability (40-50%) and has has low elimination half life(6 hr). Atenolol is mainly absorbed in the stomach. The floating tablets of atenolol were prepared to increase the gastric retention, extend the drug release and to improve the bioavailability of the drug. The floating tablets were formulated using HPMC 100 cps, sodium alginate, carbopol 9...
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