Relative afferent pupillary defects were simulated in normal individuals by performing the alternating light test while dimming the light in front of one eye with neutral density filters. Pupillary responses were elicited using a binocular photostimulator and recorded using a binocular television pupillometer. In five subjects, four spatial variables of the pupillary response--contraction ampli...

PURPOSE To assess the amount of structural loss (retinal nerve fiber layer [RNFL] thickness loss, macular thickness [MT] and volume [MV] measured by optical coherence tomography [OCT]) and functional loss (visual acuity [VA], visual field mean deviation [MD], brightness sensitivity, and red perception) necessary for a relative afferent pupillary defect (RAPD) to manifest in patients with glauco...

Summary Background To report inadvertent intraocular methylprednisolone injection into an eye that had previously undergone superior oblique tuck surgery. Material and methods An observational case report. Results penetration occurred following periorbital injection, which was performed via the superonasal quadrant to relieve trochlear pain in previous procedure. There immediate loss of vision,...

OBJECTIVE To determine the percent decussation of pupil input fibers in humans and to explain the size and range of the log unit relative afferent pupillary defect (RAPD) in patients with optic tract lesions. DESIGN Experimental study. PARTICIPANTS AND CONTROLS Five patients with a unilateral optic tract lesion. METHODS The pupil response from light stimulation of the nasal hemifield, tem...

To evaluate, using pupillography, the difference between eyes affected by age-related macular degeneration and their contralateral normal eyes with regard to the mean relative afferent pupillary defect (RAPD) score. Also, to ascertain any correlations between this difference in RAPD score and differences in visual acuity or age-related macular degeneration (AMD) dimensions. Measurements were ma...

OBJECTIVE To quantify the amount of optic nerve axonal loss associated with the presence of a mild relative afferent pupillary defect (RAPD) in an experimental monkey model. METHODS The right macula of 5 rhesus monkeys (Macaca mulatta) was treated with concentrically enlarging diode laser burns until an RAPD was detected using a transilluminator light and measured with neutral density filters...

AIMS/BACKGROUND Pupillary light response is usually defective in all types of optic neuropathy. However, the authors have observed in patients with Leber's hereditary optic neuropathy (LHON) relatively normal light response, with consequent misdiagnosis psychogenic visual loss in some cases. To confirm this clinical impression, afferent pupillary defect was assessed by measurement of adjusted c...

Relative afferent pupillary defects (RAPD) were detected in 32.3% of patients with amblyopia by a modification of the swinging flashlight test and the synoptophore. After consideration of various clinical investigations the significant factors identified in patients showing a RAPD were: anisometropia, early age of onset where strabismus was present, level of visual acuity following treatment, l...

Ocular involvement after primary infection with varicella zoster virus is very rare. We report a case of a healthy 18-year-old man who presented with unilateral ischemic retinal vasculitis 10 days after the onset of chickenpox. He developed acute severe visual loss and a relative afferent pupillary defect in his right eye. Fundus imaging, optical coherence tomography, fundus fluorescence angiog...

A 62-year-old female complained of vision loss following multiple abdominal surgeries for mesenteric ischemia. The patient’s visual acuity was no light perception (NLP) in the right eye and hand motion (HM) at 1’ in the left eye. Both pupils were unreactive and no relative afferent pupillary defect was noted. Anterior segment and fundus examination were unremarkable. T1 and T2 weighted MRI imag...