BACKGROUND AND OBJECTIVES There has been little published information on risk factors for poor long-term outcome in adult biopsy-proven minimal change disease (MCD). METHODS Data from sixty-three adult, biopsy-proven primary MCD patients treated at a tertiary university hospital between 2003 and 2013 were analyzed. Baseline clinical and pathologic factors were assessed for the associations wi...

Blocks of acid sulfate altered rock ejected from Halema`uma`u crater in the March 2008 eruption provide evidence of deeper processes that are driving the shallow hydrothermal alteration in this area. Previous work shows that the surficial alteration is dominated by remnant opal (SiO2) and anatase (TiO2), which are compositionally similar to materials found at Home Plate on Mars. The opal deposi...

the massive sulphide deposit at kantienpan cu-zn mine is hosted by volcano sedimentary succession known as the areachap group, in the eastern part of namaqua metamorphic province, south africa. the deposits were affected by a complex deformation and metamorphic history and represent examples of upper amphibolite to granulite grade metamorphosed volcanic-hosted massive sulphide (vhms) depo...

The hand stencils of European Paleolithic art tend to be considered of pre-Magdalenian age and scholars have generally assigned them to the Gravettian period. At El Castillo Cave, application of U-series dating to calcite accretions has established a minimum age of 37,290 years for underlying red hand stencils, implying execution in the earlier part of the Aurignacian if not beforehand. Togethe...

[1] We have analyzed the radar-dark parabola deposits associated with impact craters on the surface of Venus using the results of the Magellan radio experiments in both passive and active modes. The extent of mantle deposits is found to be much wider than the dark features observed in synthetic aperture radar (SAR) images. Using the emissivity data, we have classified features coinciding with t...

Amyloid deposits consist of protein fibrils and amorphous material, and this deposition is related to oxidative stress. Previously, we demonstrated the presence of high-density lipoproteins and/or lipids in amyloid deposits of familial amyloid polyneuropathy patients. In this study, the presence of myeloperoxidase (MPO) in amyloid deposits was demonstrated using immunohistochemical staining. In...

As part of an investigative nephrotoxicity study, kidney tissues from juvenile rats orally administered dabrafenib at different age intervals between postnatal day (PND) 7 to 35 were investigated by MALDI and LDI imaging mass spectrometry (IMS) to determine the chemical composition of tubular deposits. In the youngest age group (PND 7-13), MALDI IMS demonstrated that a dabrafenib carboxylic aci...

Alzheimer disease is a dementing disorder characterized pathologically by Aβ deposition, neurofibrillary tangles, and neuronal loss. Although aged animals of many species spontaneously develop Aβ deposits, only 2 species (chimpanzee and wolverine) have been reported to develop Aβ deposits and neurofibrillary tangles in the same individual. Here, the authors demonstrate the spontaneous occurrenc...