Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements in the ther-apeutic management of GERD. These include the advanced grades of erosive esophagitis, nonerosive reflux disease, main-tenance treatment of erosive ...

OBJECTIVES This study aims at verifying the prevalence of gastroesophageal reflux in asthmatic children, and at determining the sensitivity and specificity of the reflux index for the diagnosis of gastroesophageal reflux disease. METHODS Sixty-nine children, aged 1-5 years, with asthma, were studied by 24-hour pH monitoring. The patients were randomly selected. RESULTS Ages varied from 12.4...

UNLABELLED Evidence of a relation between gastroesophaeal reflux and pediatric respiratory disorders increases every year. Many respiratory symptoms and clinical conditions such as stridor, chronic cough, and recurrent pneumonia and bronchitis appear to be related to gastroesophageal reflux. Some studies have also suggested that gastroesophageal reflux may be associated with recurrent laryngeal...

BACKGROUND Duodenogastroesophageal reflux (DGER) is considered an independent risk factor for complicated reflux disease (gastroesophageal reflux disease; GERD). However, the role of DGER in GERD patients refractory to proton pump inhibitors (PPI) remains poorly understood. METHODS 85 patients with clinical reflux symptoms and a history of ineffective response to PPIs were enrolled in the stu...

In children with gastroesophageal reflux (GER) disease refractory to pharmacological therapies, anti-reflux surgery (fundoplication) may be a treatment of last resort. The applicability of fundoplication has been hampered by the inability to predict which patient may benefit from surgery and which patient is likely to develop post-operative dysphagia. pH impedance measurement and conventional m...

BACKGROUND & AIMS A history of high body mass index (BMI) is associated strongly with a risk of esophageal adenocarcinoma (EAC). We investigated whether gastroesophageal reflux is involved in this association. METHODS We analyzed data from a population-based Swedish nationwide study of patients with a new diagnosis of EAC (n = 189) or gastroesophageal junction adenocarcinoma (n = 262), and ma...

CONTEXT In infants, it is not always easy to distinguish between pathological and physiological gastroesophageal reflux based only on clinical criteria. In Brazil, studies about gastroesophageal reflux disease in infants are few and are even rare those that used prolonged esophageal pH monitoring for its evaluation. OBJECTIVE To describe the clinical features of gastroesophageal reflux diseas...

introduction: gastroesophageal reflux (ger) is the most common esophageal disorder, which occurs at all ages. ger is defined as the passage of gastric contents into the esophagus. ger disease (gerd), which is a long-term complication, is a common pediatric problem. clinical manifestations of gerd in infants include regurgitation, irritability, choking, gagging, vomiting, poor weight gain, and r...

Objective: Long-standing gastroesophageal reflux disease is the most common cause of a cicatricial stricture esophagus. The treatment this pathology involves wide range methods including conservative and surgical options. Surgeons can encounter technical difficulties in case concomitant neck chest pathology. Clinical case: We report decompensated esophagus with paraesophageal hiatal hernia, ref...

BACKGROUND The role of gastropharyngeal reflux in patients with globus pharyngeus and hoarseness remains unclear. OBJECTIVE To evaluate patients with complaints of globus, hoarseness, or globus and hoarseness combined for the presence of gastropharyngeal and gastroesophageal reflux. DESIGN Prospective clinical cohort study of 3 groups of patients undergoing ambulatory 24-hour double-probe p...