BACKGROUND & AIMS Splanchnic arterial vasodilatation plays an important role in cirrhotic ascites. The aim of this study was to evaluate the effects of long term administration of midodrine on systemic hemodynamics, renal function, and control of ascites in patients with cirrhosis and refractory or recurrent ascites. METHODS Forty cirrhotic patients with refractory or recurrent ascites were p...

A modified plate dialyser (Rhone-Poulenc) was used 318 times to concentrate ascites for reinfusion in 210 patients, most of them having longstanding ascites refractory to diuretic treatment. The advantages of this method of treatment are its rapidity and efficacy, ascites being reduced in a mean time of 21±13 hr. Hyponatraemia is easily corrected by a sodium load during reinfusion. There was im...

In cirrhosis, the natural history of hepatorenal disorders starts with a pre-ascitic stage and is followed by the development of ascites; hepatorenal syndrome (HRS) begins with compensated renal sodium retention, or pre-ascites. In pre-ascites, the renal sodium retaining tendency leads to 'overfilling' of total blood volume, with increased glomerular filtration rates (GFR), overcoming the renal...

BACKGROUND Renal hemodynamic measurements are complicated to perform in patients with cirrhosis, yet they provide the best measure of risk to predict hepatorenal syndrome (HRS). Currently, there are no established biomarkers of altered renal hemodynamics in cirrhosis validated by measured renal hemodynamics. METHODS In this pilot study, simultaneous measurements of glomerular filtration rate ...

Endoscopic ultrasound (EUS)-guided drainage is now the treatment of choice in cases of pancreatic pseudocysts and walled-off necrosis, especially in the absence of luminal bulging and in patients with portal hypertension. Malignant refractory ascites usually heralds a poor prognosis and substantially impairs the quality of life of patients because of the symptoms experienced and the need for re...

Clinical care of patients with polycythemia vera, essential thrombocythemia and myelofibrosis (MF) requires not only a broad understanding of general treatment principles but also familiarity with the management of hydroxyurea-refractory disease complications. The latter include progressive splenomegaly, symptomatic portal hypertension (e.g. ascites, variceal bleeding), pulmonary hypertension, ...

Background & AimsAscites has been classified according to quantity and response medical therapy. Despite its precise definitions, little is known about the effects of grade 1 ascites or recurrent (i.e. that recurs at least on 3 occasions within a 12-month period despite dietary sodium restriction adequate diuretic dosage) patient outcome. We studied progression in large cohort outpatients with ...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial The aim of a transjugular intrahepatic portosystemic shunt (TIPS) is to shunt blood from the hypertensive portal vein to the hepatic vein, thereby nonsurgically decompressing the portal pressure. This procedure is generally used to treat complicati...