BACKGROUND In all IVF programmes, some patients fail to achieve an ongoing pregnancy, even after numerous embryo transfer procedures. An unfavourable environment within the uterus might be a contributory factor to such recurrent implantation failure. This question was addressed by measuring cytokine concentrations and matrix metalloproteinase activities in fluid derived from uterine irrigation ...

background: implantation failure is one of the most important factors limiting success in ivf treatment. the majority of trials have demonstrated favorable effect of endometrial injury on implantation success rate especially in women with recurrent implantation failure, while some studies failed to detect any benefit. objective: the purpose of our trial was to explore whether endometrial injury...

Implantation failure is the most frequent cause of pregnancy loss in couples who try to conceive, either in a natural way or using assisted reproductive techniques (ART). Identify the precise mechanisms of implantation failure can lead to identify couples at risk and also providing appropriate therapeutic options to affected couples. Despite the high prevalence of this disorder, a few causing f...

Abstract Recurrent implantation failure (RIF) is an imprecisely defined disorder lacking a robust scientific basis. The incomplete understanding of RIF provides significant diagnostic and therapeutic challenges, better the underlying issues necessary to improve outcomes. We propose novel concept termed ‘Theoretical Cumulative Implantation Rate’, calculation which based on objective data, define...

Embryo implantation represents the most critical step of the reproductive process in many species. Inadequate uterine receptivity is responsible for approximately two-thirds of implantation failures. The cell adhesion molecule (CAM) such as integrins, cadherins, selectins and immunoglobulins intervene to ensure adhesiveness between the embryo and the endometrium. Some recent studies indicate th...

ObjectiveTo present a definition of recurrent implantation failure that accounts for the effects female age and anticipated blastocyst euploidy rates on cumulative rates.DesignMathematical modeling.SettingNot applicable.Patient(s)Not applicable.Intervention(s)Mathematical modeling probability basis published across categories age.Main Outcome Measure(s)The number blastocysts required to achieve...

Background: To screen and diagnose patients with recurrent abortions and implantation failure after IVF/ICSI, differentially expressed genes of endometrium through DNA microarrays were monitored. Materials and Methods: Microarray expression profile of GSE26787 dataset from GEO database was used to analyze gene expression profiles of 15 endometrial biopsy samples- five from control fertile (CF) ...

Background: Recurrent pregnancy loss (RPL), defined as 3 or more consecutive pregnancy failures, is a common and distressing disorder. Chromosome instability in the conceptus is the most common cause whereas uterine factors are invariably invoked to explain nonchromosomal miscarriages. These uterine factors are, however, poorly defined. Materials amd Methods: Laboratory-based analysis of endome...