Genetic reference populations in model organisms are critical resources for systems genetic analysis of disease related phenotypes. The breeding history of these inbred panels may influence detectable allelic and phenotypic diversity. The existing panel of common inbred strains reflects historical selection biases, and existing recombinant inbred panels have low allelic diversity. All such popu...

Female mice of 16 inbred mouse strains were fed an atherogenic diet for 14 weeks and were then evaluated for atherosclerotic lesions in the aorta. Strains C57BL/6, C57BR/cd, C57L, and SM were very susceptible to atherosclerosis, with lesion area/aortic cross-sections in the range of 4500 to 8000 microns 2. Strains C58 and SWR were intermediate in susceptibility, with lesion area/sections in the...

Restriction fragment length polymorphisms have been identified between inbred strains of mice for the homeo box gene complex Hox-2. These genetic markers were used to follow the segregation of different Hox-2 alleles among recombinant inbred strains of mice and among the progeny of a three point genetic cross. The results place the Hoax-2 locus approximately 1 cM from the rex (Re) locus on mous...

Winter hardiness is a complex trait and poor winter hardiness limits commercial production of winter oat (Avena spp.). The objective of this study was to identify quantitative trait loci (QTL) for fi ve winter-hardiness component traits in a recombinant inbred line population derived from a cross between the winter-tender cultivar Fulghum and the winter-hardy cultivar Norline. Crown freezing to...

Common bean is the most accessible protein source to population and daily consumed. Studies using both morphoagronomic markers molecular have been used in breeding programs. This work aimed study diversity of 22 recombinant inbred lines and, their progenitors with aid SSR markers. The crossing occurred a greenhouse, between cultivar BRS Agreste black-01 line. characters that showed polymorphism...

Locating quantitative trait loci (QTL) in mammalian systems has proven difficult due to the lack of genetic control and reproducibility, as well as the expense of maintaining sufficiently large populations for genotyping and phenotyping. In plants, populations of recombinant inbred lines (progeny bred to homozygosity from a single cross) do not have these problems. Methods developed to identify...