Models of the human μ opioid receptor were constructed using available G-protein-coupled receptor (GPCR) structures using homology (comparative) modeling techniques. The recent publication of a high-resolution crystal structure of a construct based on the murine μ opioid receptor offers a unique opportunity to evaluate the reliability of the homology models and test the relevance of introducing...

•m6A is an endogenous adenosine A3 receptor ligand with higher potency than •Extracellular m6A mainly stems from ribosomal RNA and mRNA •Cytotoxic stimulation induces release via lysosome-mediated catabolism facilitates allergy inflammation About 150 post-transcriptional modifications have been identified in all kingdoms of life. During catabolism, most modified nucleosides are resistant to deg...