Ramadan is the Holy month of fasting that is obligatory for all normal Muslims who reached at their puberty. Two meals are taken during Ramadan, one is taken before down to prepare themselves for fast is called “Sahur”, and second meal is taken at sunset is called “Iftar”. Fasting is not only a ritual and religious obligation while it has several medicinal significances specia...

Background: Endometriosis is a disease which is defined by the growth of endometrium-like tissue outside of the uterine cavity. Literatures show that VEGF by interaction with their receptors, Flt-1 (Fms-like tyrosine kinase-1 or VEGFR-1) and Flk-1/KDR (fetal liver kinase/ kinase-insert domain receptor or VEGFR-2) is related to pathogenesis of endometriosis. The purpose of this study was to eval...

objective(s) using a cancer murine model of invasive aspergillosis (ia), we investigated the expression of tlr-2, dectin-1 and the level of cytokine production by cd4+ t helper cells in different groups of mice (with or without cancer), also, the effect of invasive aspergillosis on the immune response pattern of cancer mice. materials and methods patterns of susceptibility and resistance to inf...

background macrophages play critical roles in innate immune response in the liver. whether macrophages participate in liver innate immunity against hcv replication is poorly understood objectives the aim of this study was to investigate the role of macrophages in liver innate immunity against hcv replication. conclusions macrophages may play an important role in liver innate immunity against hc...

Abstract Low-density lipoprotein (LDL) accumulation in the arterial wall contributes to atherosclerosis initiation and progression 1 . Activin A receptor-like type (ACVRL1, called activin-like kinase receptor (ALK1)) is a recently identified that mediates LDL entry transcytosis endothelial cells (ECs) 2,3 However, role of this pathway vivo not yet known. In present study, we show genetic deleti...

The insulin-like growth factor-1 receptor (IGF-1R) is a transmembrane receptor with tyrosine kinase activity. The receptor plays a critical role in cancer. Using monoclonal antibodies (MAbs) against the IGF-1R, typically blocks ligand binding and enhances down-regulation of the cell-surface IGF-1R. Some MAbs such as cixutumumab are under clinical trial investigation. Targeting multiple distinct...

Background: Necroptosis is a novel programmed cell death pathway proposed in 2005, which mainly activated by the tumor necrosis factor (TNF) family and mediates cellular disassembly via receptor interacting serine/threonine kinase 1 (RIPK1), 3 (RIPK3) mixed lineage domain like pseudokinase (MLKL). We tried to analyze relationship of necroptosis-related genes (NRGs) expression with colon adenoca...

Ginsenoside F1 is a biologically active compound identified potential from Korean Panax ginseng Meyer. In the present study, the potential targets of ginsenoside F1 were investigated by computational target fishing approaches including ADMET prediction, biological activity prediction from chemical structure, molecular docking, and molecular dynamics methods. Results were suggested to express th...