نتایج جستجو برای: rb domains
تعداد نتایج: 185704 فیلتر نتایج به سال:
The cell cycle-regulating transcription factors E2F1/DP1 activate genes whose products are required for S phase progression. During most of the G1 phase, E2F1/DP1 activity is repressed by the retinoblastoma gene product RB, which directly contacts the E2F1 activation domain and silences it. The E2F1 activation domain has sequence similarity to the N-terminal activation domain of E1A(12S), which...
background: the role of retinoblastoma (rb) protein in cell cycle regulation prompted us to take up this study with the aim of assessing its role in the progression of oral cancer and to correlate with various clinicopathological parameters, including habits such as smoking, paan chewing, and alcoholism. materials and methods: this observational study included surgical specimens from 10 apparen...
Inspired by recent analyses of the finite element heterogeneous multiscale method and the reduced basis technique for nonlinear problems, we present a simple and concise finite element algorithm for the reliable and efficient resolution of elliptic or parabolic multiscale problems of nonmonotone type. Solutions of appropriate cell problems on sampling domains are selected by a greedy algorithm ...
فضای سبز شهری در مناطق گوناگون جهان جزء ضروریات روزمره و جذابیت های محلی است. انتخاب گونه های مقاوم به خشکی برای کاشت در فضای سبز شهری در مناطق خشک و نیمه خشک به منظور ایجاد تنوع امری ضروری است. یکی از آزمایش های مهم سازگاری، به منظور معرفی گیاهان در مناطق جدید، بررسی ظهورشناسی گونه هاست. هدف اصلی این تحقیق شناسایی خصیصه های ظهورشناسی گونۀ بلوط به دو روش توصیفی و با استفاده از سری زمانی عکس برد...
The activity of P-type plasma membrane H(+)-ATPases is modulated by H(+) and cations, with K(+) and Ca(2+) being of physiological relevance. Using X-ray crystallography, we have located the binding site for Rb(+) as a K(+) congener, and for Tb(3+) and Ho(3+) as Ca(2+) congeners. Rb(+) is found coordinated by a conserved aspartate residue in the phosphorylation domain. A single Tb(3+) ion is ide...
We report on the magnetic phases of quasi-two dimensional Rb F = 1 spinor gases produced by cooling unmagnetized gases into the regime of quantum degeneracy. We find a robust low temperature magnetic phase characterized by crystalline ordering of spin domains, an instance of spontaneously broken translational symmetry in a quantum fluid. This phase displays an emergent order parameter, a spin a...
Whether invasive mucinous adenocarcinoma (IMA) and colloid adenocarcinoma (ICA) of the lung represent separate tumour entities, or simply lie within a spectrum of phenotypic variability, is worth investigating. Fifteen ICA, 12 IMA, 9 ALK-rearranged adenocarcinomas (ALKA), 8 non-mucinous KRAS-mutated adenocarcinomas (KRASA) and 9 mucinous breast adenocarcinomas (MBA) were assessed by immunohisto...
We have investigated the mechanism by which the simian virus 40 large T antigen (SVLT) interferes with the differentiation of C2 myoblasts. SVLT mutants, defective either in the Rb binding site, near the N-terminal end, in a region that affects binding to p53, or in the nuclear transport signal, were also employed to determine whether the interference was especially dependent on these functiona...
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