Chaperonins are known to maintain the stability of the proteome by facilitating the productive folding of numerous misfolded or aggregation-prone proteins and are thus essential for cell viability. Despite their established importance, the mechanism by which chaperonins facilitate protein folding remains unknown. Computer simulation techniques are now being employed to complement experimental o...

T study of lactic acid (HLa) and muscular contraction has a long history, beginning perhaps as early as 1807 when Berzelius found HLa in muscular fluid and thought that ‘‘the amount of free lactic acid in a muscle [was] proportional to the extent to which the muscle had previously been exercised’’ (cited in ref. 1). Several subsequent studies in the 19th century established the view that HLa wa...

Starting from ab initio electronic structure results we study dynamics of potassium ions in the pyrochlore superconductor KOs2O6. An effective ionic Hamiltonian characterized by an on-site instability rattler and frustrated nearest-neighbor interaction is derived and various approximations are investigated. We show that qualitative differences in the properties of KOs2O6 and its analogs RbOs2O6...

An interactive museum exhibit of a digitally augmented medieval musical instrument, the tromba marina, is presented. The tromba marina is a curious single stringed instrument with a rattling bridge, from which a trumpet-like timbre is produced. The physical instrument was constructed as a replica of one found in Musikmuseet, a musical instrument museum in Copenhagen, Denmark. The replica instru...