Ras protein signaling pathways are important in controlling the plight of different types of cancer. Here we discussed the paper entitled "Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling" published in Nature journal on inactivating the kinase suppressor of Ras (KSR) protein using a small molecule as an inhibitor by Dhawan et al. A biphenyl ether analo...

Background and Aim: Recurrent aphthous stomatitis (RAS) is one of the most common lesions in the oral mucosa. The etiopathogenesis of RAS is not clear. RAS is multifactorial, and several factors can contribute to RAS development. This study aimed to evaluate the RAS prevalence and some related factors in 12-17-year-old schoolchildren in Zahedan City (Southeast of Iran). Materials and Methods: ...

In eukaryotes, GTP-binding proteins act as versatile molecular switches whose active or inactive state depends on the binding of GTP or GDP, respectively (Bourne et al., 1990). The rapidly growing family of small GTP-binding proteins (mo1 wt values between 20,000 and 36,000) is now generally subdivided into three major subfamilies: Ras-like, Rho-like, and Ypt/Rab-like proteins. Each group seems...

bind both of these cellular targets to enable ferroptosis? Previous studies showed that erastin inhibits VDACmediated transport of NADH into mitochondria, thus raising the possibility that erastin’s effects on VDAC may help to elevate cytosolic levels of NADPH to support the activity of cytosolic oxidases that generate lethal levels of ROS (Yagoda et al., 2007; Yang and Stockwell, 2008). Conseq...

With an aging population, renovascular hypertension has become a major public health problem (Safian & Textor, 2001). Although various forms of fibromuscular disease of the renal arteries and/or traumatic disruption of renal vessels are the most common cause of RVH among the younger individuals, atherosclerotic renal artery disease (ARAD) is the most common lesion producing hypertension by far ...

Lung cancer is the most frequent cancer worldwide still. There were more than 1.8 million new cases (13% of total cancer incidence) and almost 1.6 million deaths (20% of total cancer mortality), as estimated in 2012 (WIL, D2014). Moreover, Lung cancer is the leading cause of cancer death in men in 87 countries and in women in 26 countries. Despite the advent of new diagnostic techniques, most l...

The renin-angiotensin system (RAS) plays a crucial role in the regulation of blood pressure (Laragh, 1995). Within the RAS, the physiological relevance of renin binding protein (RnBP) has been controversial for several years (Schmitz et al., 2000). Originally, RnBP was identified as a protein in the kidney that was capable of binding renin in renal homogenates giving rise to a complex designate...

Among the most important targets for chemopreventive intervention and drug development are deregulated signal transduction pathways. Ras proteins serve as central connectors between signals generated at the plasma membrane and nuclear effectors; thus, disrupting the Ras signaling pathway could have significant potential as a cancer chemopreventive strategy. Target organs for Ras-based chemoprev...

Gait and gait related mobility are among the most important factors for the quality of life of patients suffering from Parkinson's disease (PD). In most patients gait and gait related mobility will first lead to patients having to undergo physiotherapy. For gait training in PD there are a variety of evidence-based and well-established therapies. Among such therapies are Nordic walking, treadmil...