نتایج جستجو برای: ras 40

تعداد نتایج: 361655  

Journal: :Journal of the Egyptian National Cancer Institute 2013
Mahmoud Tag Elsabah Iman Adel

BACKGROUND The monoclonal antibodies (mAbs) that target the epidermal growth factor receptor (EGFR) had expanded the range of treatment options for metastatic colorectal cancer. However, such type of treatment was shown to be ineffective if there is K-ras mutation. In most previous studies K-ras gene mutation was mainly assessed by PCR. AIM Our work is designed to detect K-ras protein express...

افسانه شرکت زهرا مشفق علی‌اصغر بانویی محدثه سلیمانی گلروز رمضان‌زاده ولیس

علیرغم معرفی و بکارگیری روشهای متعدد بهنگام‌سازی ماتریس ضرایب مستقیم داده- ستانده در شش دهه گذشته، هنوز نکاتی از روشهای RAS و RAS تعدیل شده وجود دارند که در سالهای اخیر توجه تحلیلگران اقتصاد داده- ستانده را به خود معطوف کرده است. یکی از این نکات چالش برانگیز رابطه بین اطلاعات برونزا، برتر و یا اضافی بیشتر سال مقصد در روش RAS تعدیل شده و کاهش خطاهای آماری آن نسبت به RAS متعارف در بهنگام‌سازی ضرا...

Journal: :Pancreas 2009
Jan Däbritz Roman Preston Joachim Hänfler Helmut Oettle

OBJECTIVE We followed up the presence of Kirsten rat sarcoma (K-ras) mutations in plasma DNA and assessed its clinical value in patients with pancreatic cancer. METHODS Plasma samples (N = 430) of 56 patients with pancreatic cancer and 13 patients with pancreatitis were analyzed by real-time polymerase chain reaction using peptide nucleic acid-mediated polymerase chain reaction clamping. RE...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1986
I S Sigal J B Gibbs J S D'Alonzo E M Scolnick

To identify the amino acid residues of the Harvey (Ha) ras-encoded protein that are involved in protein-protein interactions, we have created a series of mutant Ha-ras proteins. In particular, amino acid substitutions have been introduced within two regions, residues 32-42 and 61-80, that are conserved among ras proteins from different species. We observed that amino acid substitutions at posit...

2009
Pamela K. Kreeger Roli Mandhana Shannon K. Alford Kevin M. Haigis Douglas A. Lauffenburger

The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Multiple Pathways are Impacted by Variations in RAS 2 ABSTRACT Over 40% of colon cancers have a mutation in K-RAS or N-RAS, GTPases that operate as central hubs for multiple key signaling pathways within the cell. Utilizing an isogenic panel of colon carcinoma cells with K-RAS ...

Journal: :iranian journal of nuclear medicine 2002
shahram dabiri oskooie h argani

renal artery stenosis (ras) is the most common cause of secondary hypertension. preliminary data indicate that aspirin renography with hippurate may be more sensitive for detection ras. in this study 20 patients with known or suspected ras underwent aspirin renography (20 mg/kg orally 1 hour before injection of radiotracer) and captopril renography (50 mg orally) with 99mtc-dtpa. renal angiogra...

Bahareh Nazemi Salman Ebrahim Shahdadi Rezazadeh Fahimeh Salah Shilan

Background: Recurrent aphthous stomatitis (RAS) is among the most common oral lesions and pain is often the chief complaint of patients. The main etiology of RAS is unknown but several predisposing factors have been suggested. This study aims to assess the correlation of blood types (ABO/Rh) with RAS. Methods: We conducted this prospective screening study on 50 patients with RAS and 50 controls...

H Argani Shahram Dabiri Oskooie

Renal artery stenosis (RAS) is the most common cause of secondary hypertension. Preliminary data indicate that aspirin renography with hippurate may be more sensitive for detection RAS. In this study 20 patients with known or suspected RAS underwent aspirin renography (20 mg/kg orally 1 hour before injection of radiotracer) and captopril renography (50 mg orally) with 99mTc-DTPA. Renal an...

Background and purpose: Recurrent aphthous stomatitis (RAS) or oral aphthous are among the most common problems in adults. Stressful events could cause these ulcers. The purpose of this study was to determine the prevalence of recurrent aphthous stomatitis among students in Mazandaran University of Medical Sciences and its relationship with anxiety. Materials and methods: In this analytical cr...

Journal: :Annals of Oncology 2023

Therapeutic strategies for colo-rectal relies on several parameters among which microsatellite (MS) and RAS/RAF status have important value. The aim of our study was to analyze combined MS in colorectal carcinoma (CCR). We a series 73 cases CCR with nodal/visceral metastasis. determined by immunohistochemistry. Molecular testing performed the RT-PCR automatized Idylla system. 67 were MS-profici...

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