Sphingoid intermediates accumulate in response to a variety of stresses, including heat, and trigger cellular responses. However, the mechanism by which stress affects sphingolipid biosynthesis has yet to be identified. Recent studies in yeast suggest that sphingolipid biosynthesis is regulated through phosphorylation of the Orm proteins, which in humans are potential risk factors for childhood...

Plants are able to recognize even small changes in surrounding temperatures to optimize their growth and development. At warm temperatures, plants exhibit diverse architectural adjustments, including hypocotyl and petiole elongation, leaf hyponasty, and reduced stomatal density. However, it was previously unknown how such warm temperatures affected the early stages of seedling development. In o...

Rat liver microsomal membranes were purified in order to remove membrane-associated secretory products. Measurements of the decay of the newly synthesized protein of these membranes in vivo were carried out at short time intervals after the protein was labeled by the administration of radioactive leucine. The result of these measurements suggest that the membranes are synthesized and degraded a...

By 1959, Eugene Kennedy and coworkers had outlined most pathways of phospholipid biosynthesis. In the next four decades, the emphasis was on enzymology and regulation of these pathways. In the last 12 years, several lines of mice with disrupted genes of phospholipid biosynthesis were generated. From this research, we have learned that embryonic lethality occurs in mice that lack choline kinase ...

background the production of nanoparticles using a biosystem is considered green chemistry. application of plant extracts as a biological process has been proven to be suitable for synthesis of nanoparticles. objectives this study designed in order to evaluate the production of silver nanoparticles using juglans regia leaf extract and to compare the outcome of different preparation methods of p...

This study provides new insights into the role of photoprotection in preformed and induced defence two wheat genotypes with contrasting phenotypes to infection by Zymoseptoria tritici. We investigated mechanisms photoprotective response during early infection, including nonphotochemical quenching (NPQ), β-carotene-derived xanthophylls, reactive oxygen species, phytohormones abscisic acid (ABA),...

The GSH:GSSG ratio, which is the primary determinant of the cellular redox state, becomes progressively more pro-oxidizing during the aging process due to an elevation in the GSSG content and a decline in the ability for de novo GSH biosynthesis. The K(m) of glutamate-cysteine ligase (GCL), the rate-limiting enzyme in de novo GSH biosynthesis, significantly increases during aging, which would a...

in this study, the biosynthesis of gold nanoparticles by penicillium chrysogenum, isolated from ahar copper mine, was investigated. the gold nanoparticles were synthesized by reducing the aqueous gold ions using the culture supernatant of the filamentous fungi. the uv–vis spectrum displayed a characteristic peak at 532 nm that is very specific for gold nanoparticles. the xrd spectrum confirmed ...