The hypothesis that a toxic hemolytic substance could be recovered from the stools of pernicious anemia patients was investigated. Saline stool extracts of patients suffering from pernicious anemia and those of normal individuals were administered to rabbits by intravenous and subcutaneous injection over long periods of time. Stool extracts prepared by the special technique of Seyderhelm (1) we...

Studies in Cucinogenesis. V. Methyl Derivatives of 1 : 2-Benzanthracene, M. J. SHEAR. In a further contribution to his series of studies on carcinogenesis Shear records his experiments with the methyl derivatives of 1 : 2-benzanthracene and related compounds. Of 21 compounds examined 10 produced tumors in mice a t the injection site. The more potent carcinogenic compounds were 5 : 10-dimethyl-1...

An active transmissible virus exists in the blood of measles patients during the eruptive stage of the disease. This virus produces in rabbits after intravenous injection a specific reaction analogous in all essential features to that of the human infection. Following a definite incubation period of from 2 to 5 days the animals infected show pyrexial, leucocytic, and cutaneous alterations. Full...

By AKIRA S. KA IoTo, I\I.D. I x A P1IEVIOUS PAPER on exj)erimental leukemia’ the author has demonstrated that various kinds of human leukemias could he transmitted serially to fowls 1w cell-free filtrates. Liver emulsions (lerive(i form 7 cases of leukemia (acute ttlRl chronic myeloid or lymphatic leukemia, chloroleukemia, aleukemic lymphatic leukemia afl(1 myelosis erythraemica,2 were administ...

1. The infectious agent from fatal cases of St. Louis and Kansas City encephalitis passes Seitz pads in high dilution without appreciable loss of infectivity and traverses collodion membranes with an average pore size of 66 mmicro or greater. 2. It is highly infectious for mice by the intracerebral and intranasal routes, but practically innocuous by the subcutaneous and intraperitoneal routes. ...

Video recording technology allows for the discovery of psychological phenomena that might otherwise go unnoticed. We focus here on gesture as an example of such a phenomenon. Gestures are movements of the hands or body that people spontaneously produce while speaking or thinking through a difficult problem. Despite their ubiquity, speakers are not always aware that they are gesturing, and liste...

BACKGROUND Reducing the worldwide mortality ratio by 75 per cent between 1990 and 2015 is a key Millennium Development Goal. Randomized controlled trials (RCTs) are the accepted 'gold standard' to assess the effectiveness of interventions but they are not always appropriate for practical, ethical or economic reasons in developing countries. This study examines the use of cluster randomized tria...

Study of the pathology of pneumonia experimentally produced in monkeys by the intratracheal injection of pneumococcus has shown that it is identical with the pathology of lobar pneumonia in man. It has been found that the pneumococcus primarily invades the pulmonary tissue at some point or points in the portion of the lobe proximal to the hilum, that it spreads rapidly throughout the lobe by wa...

Our observations show that young rabbits born of mothers afflicted with Schistosomum japonicum develop typical rickets. Rickets can also be produced if we infect the young, healthy rabbits with the same parasite. It is natural to suppose that the rachitic changes are caused by the parasite itself. Since, however, a similar disease can be produced in the offspring, when the mother is fed on egg ...

A method is described whereby immune complexes may be visualized in a single cell. Bovine serum albumin labeled with a red-fluorescing dye was joined to a rabbit antiserum labeled with a green-fluorescing dye to yield an immune complex which fluoresced yellow when illuminated by ultraviolet light. Such yellow-fluorescing immune complexes were injected into the peritoneal cavity of guinea pigs, ...