نتایج جستجو برای: randomized control trials
تعداد نتایج: 1650416 فیلتر نتایج به سال:
BACKGROUND AND PURPOSE The methodological quality of randomized controlled trials (RCTs) is commonly evaluated in order to assess the risk of biased estimates of treatment effects. The purpose of this systematic review was to identify scales used to evaluate the methodological quality of RCTs in health care research and summarize the content, construction, development, and psychometric properti...
BACKGROUND AND AIM: Randomized controlled trials (RCTs) are the gold standard for providing evidence in clinical research. The present study was performed with the objective to assess the quality of reports of RCTs in orthodontics in PubMed-indexed journals published by Iranian authors from 2007 to 2017.METHODS: All the articles on orthodontics published from 2007 to 2017 and indexed in PubMed ...
whAt Is the PRoBleM? Different from trials for regulatory approvals of new interventions aimed to test the efficacy, comparative effectiveness research (CER) is the direct comparison of existing health‐care interventions (compared with active controls) to examine which treatment works best, for whom, and under what settings.[1] Therefore, CER is indispensable to assist consumers, clinicians, pu...
The CONSORT (Consolidated Standards of Reporting Trials) Statement aims to improve the reporting of randomized controlled trials (RCTs); however, it lacks guidance on the reporting of patient-reported outcomes (PROs), which are often inadequately reported in trials, thus limiting the value of these data. In this article, we describe the development of the CONSORT PRO extension based on the meth...
OBJECTIVE Poor patient adherence to lipid-lowering medication is a major contributory factor in the lack of success in treating hyperlipidaemia. The objective of this review was to assess the effect of adherence-enhancing interventions for lipid-lowering medication. DESIGN Systematic review of randomized controlled trials (RCTs). DATA SOURCES Cochrane Central Register of Controlled Trials (...
Randomized controlled trials (RCTs) have historically been considered the primary source of evidence to support decision-making in market access and reimbursement. However, thanks to significant progress in capturing data through computerized systems and making these data available, real-world evidence (RWE) has been increasingly considered by manufacturers and payers. Despite initiatives and r...
IMPORTANCE The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. The epidemiology of discontinued RCTs, however, remains unclear. OBJECTIVES To determine the prevalence, characteristics, and publication history of discontinued RCTs and to investigate factors associated with RCT discontinuation due to poor recruitment and w...
We investigate examples of quasi-spectral triples over two-dimensional commutative sphere, which are obtained by modifying the order-one condition. We find quasi-Dirac operators and calculate the index paring with a representant of K-theory class to prove that the quasispectral triples are mutually inequivalent. MSC 2000: 58B34, 46L87, 34L40
We apply Bayesian decision analysis (BDA) to incorporate patient preferences in the regulatory approval process for new therapies. By assigning weights to type I and type II errors based on patient preferences, the significance level (α) and power (1-β) of a randomized clinical trial (RCT) for a new therapy can be optimized to maximize the value to current and future patients and, consequently,...
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