نتایج جستجو برای: randomised control trial
تعداد نتایج: 1607751 فیلتر نتایج به سال:
BACKGROUND The UK Lung Cancer Screening (UKLS) trial is a randomised pilot trial of low-dose CT (LDCT) screening for individuals at high risk of lung cancer. We assessed the long-term psychosocial impact on individuals participating in the UKLS trial. METHODS A random sample of individuals aged 50-75 years was contacted via primary care. High-risk individuals who completed T0 questionnaires (...
INTRODUCTION Self-monitoring of blood glucose (SMBG) has been underutilised. We conducted an open-label, randomised controlled trial to assess the feasibility of introducing SMBG in primary care clinics in Malaysia. METHODS This was an open-label, randomised controlled trial conducted in five public primary care clinics in Malaysia. Patients with type 2 diabetes mellitus (age range 35-65 year...
All studies were categorised according to the strength of the evidence based on the following revised classification system. Level I Evidence obtained from a systematic review of all relevant randomised controlled trials. Level II Evidence obtained from at least one properly designed randomised controlled trial. Level III.1 Evidence obtained from well designed pseudo-randomised controlled trial...
BACKGROUND High blood pressure during acute stroke is associated with poorer stroke outcome. Previous trials have failed to show benefit from lowering blood pressure but treatment may have been commenced too late to be effective. The earliest that acute stroke treatments could be initiated is during contact with the emergency medical services (paramedics). However, experience of pre-hospital cl...
In the early days of randomised control trials the ability to reduce confounding fromknownand unknown confounders rightly underpinned their rapid rise in methodological popularity. Ever since, however, concerns have been expressed by the clinician community and others about the difficulty of applying estimates of effects derived from randomised control trials to settings and patient populations...
BACKGROUND Research has shown that obese individuals have cognitive deficiencies in executive function, leading to poor planning and impulse control, and decision-making difficulties. An intervention that could help reduce these deficits and in turn help weight loss maintenance is Cognitive Remediation Therapy for Obesity (CRT-O). We aim to examine the efficacy of manualised CRT-O, which is int...
Most randomised trials allocate individual participants to different treatments. However, cluster randomised trials in which groups of subjects are allocated to different treatments are becoming increasingly popular. Cluster randomisation is often advocated to minimise treatment “contamination” between intervention and control participants. For example, in a trial of dietary change, people in t...
OBJECTIVE To assess the feasibility of a pre-operative occupational therapy intervention for patients undergoing primary total hip replacement. DESIGN Single blinded feasibility randomised controlled trial, with data collection prior to the intervention, and at 4, 12, and 26 weeks following surgery. SETTING Recruitment from two NHS orthopaedic outpatient centres in the West Midlands, UK. ...
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