The cytosolic nuclear transport factor p10/NTF2 is required for the translocation of karyophilic molecules through nuclear pores [1] [2] [3], and the small GTPase Ran is a key regulator of protein transport between the nucleus and cytoplasm [4] [5]. It has been reported that p10/NTF2 interacts directly and specifically with Ran-GDP but not with Ran-GTP [6]. The precise role(s) of p10/NTF2 in th...

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The recent controversy over model selection in the context of ‘growth regressions’ has led to some remarkably numerous ‘estimation’ strategies, including 4 million regressions by Sala-i-Martin (1997b). Only one regression is really needed, namely the general unrestricted model, appropriately reduced to a parsimonious encompassing congruent representation. Such an outcome was achieved in one run...

Rapid automatized naming (RAN) is strongly related to literacy gains in developing readers, reading disabilities, and reading ability in children and adults. Because successful RAN performance depends on the close coordination of a number of abilities, it is unclear what specific skills drive this RAN-reading relationship. The current study used concurrent recordings of young adult participants...

A small GTPase Ran is a key regulator for active nuclear transport. In immunoblotting analysis, a monoclonal antibody against recombinant human Ran, designated ARAN1, was found to recognize an epitope in the COOH-terminal domain of Ran. In a solution binding assay, ARAN1 recognized Ran when complexed with importin beta, transportin, and CAS, but not the Ran-GTP or the Ran-GDP alone, indicating ...

INTRODUCTION Pancreatic ductal adenocarcinoma (PDA) has the worst prognosis among cancers, mainly due to the high incidence of early metastases. RAN small GTPase (RAN) is a protein that plays physiological roles in the regulation of nuclear transport and microtubule spindle assembly. RAN was recently shown to mediate the invasive functions of the prometastatic protein osteopontin (OPN) in breas...

In this paper we take an overall look at key technical challenges in the evolution of the Radio Access Network (RAN) architecture towards Cloud RAN, and solutions to overcome them. To address fronthaul limitations, we examine the implications and tradeoffs enabled by functional splits on fronthaul needs, system performance, and centralization scale. We examine the architecture of algorithms for...