Two important facts have drawn the attention of medical men to radio-activity. The first fact was the observation that radium rays affect the tissues of the human bod}\ For ljke Ronto-enrays they are able to cause serious injuries to&the skin. The first man who tried to utilise radium rays for medical purposes was Dr. Danlas of the St. Louis Hospital in Paris, who used them successfully to cure...

Background Baseline clinical variables are prognostic for overall survival (OS) in patients with castration-resistant prostate cancer (CRPC). Their prognostic and predictive value with agents targeting bone metastases, such as radium-223, is not established. Patients and methods The radium-223 ALSYMPCA trial enrolled patients with CRPC and symptomatic bone metastases. Prognostic potential of ...

The spatial distribution of (238)U-series radionuclides, specifically 238U, 234U, 230Th and 226Ra, has been determined in stream sediments from Edale, Derbyshire, United Kingdom, to explore the behaviour of U-series radionuclides during weathering. For uranium and thorium, two different extraction methods were used, total dissolution with HNO3/HF in a microwave and leaching with aqua regia. Thi...

Becquerell has observed that p-rays change yellow phosphorus into red form. Ramsey* and Cameron* have shown that the radium emanation has destruotive and partial synthetic actions upon water, carbon monoxide, carbon dioxide, hydrogen chloride, and ammonia. The decomposing action of radium rays on the lecithin molecule has been observed by Schwara,4 Schaper,& and Werner.6 On the other hand, no s...

Radium-223 dichloride (radium-223) is an important therapeutic option for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases, and no visceral disease. The unique mechanism of action of this first-in-class alpha-emitting radiopharmaceutical underlies its favorable safety profile and low incidence of myelosuppression. In the pivotal phase 3 ALpharadin...

The present study was undertaken with a view of determining in a general way the effects of intravenous administration of radium upon the circulation and respiration. The problem was suggested to us by Dr. William J. Gies, under whose guidance a number of researches, dealing with the more extensive question of the action of radium upon animal and vegetable cells, have recently been carried on i...

Radium-223 is a first-in-class alpha particle-emitting radiopharmaceutical approved for the treatment of bone metastatic castration-resistant prostate cancer. Radium-223 is administered intravenously with no requirement for complex shielding and specifically targets areas of bone metastasis. In a randomized placebo-controlled Phase III study, treatment with radium-223 was shown to improve overa...

Background: Ondo city in Ondo State Nigeria includes Ondo East and West could be described as a research city due to antecedent number of research institutes. Materials and Methods: Dose due to radioactivity content of soil samples from sixteen waste dump sites in Ondo, Southwestern Nigeria was determined using gamma-ray spectrometer in order to evaluate the radiation hazard health profile and ...

OBJECTIVE This open-label, non-randomized, phase I study examined the pharmacokinetics (PK) and radiation dosimetry of a single dose of radium-223 in Japanese patients with castration-resistant prostate cancer (CRPC) and bone metastases. METHODS Six male Japanese patients (mean age 72.5 years, range 65-79 years) with histologically or cytologically confirmed stage IV adenocarcinoma of the pro...