BACKGROUND Radium-223 dichloride (radium-223), an alpha emitter, selectively targets bone metastases with alpha particles. We assessed the efficacy and safety of radium-223 as compared with placebo, in addition to the best standard of care, in men with castration-resistant prostate cancer and bone metastases. METHODS In our phase 3, randomized, double-blind, placebo-controlled study, we rando...

A field experiment to compare methods of assessing submarine groundwater discharge (SGD) was held on Shelter Island, NY, in May 2002. We evaluated the use of radon, radium isotopes, and methane to assess SGD rates and dynamics from a glacial aquifer in the coastal zone. Fluxes of radon across the sediment-water interface were calculated from changes in measured surface water inventories followi...

BACKGROUND Bone metastases are associated with increased morbidity and poor prognosis in breast cancer patients. Radium-223 dichloride is a calcium mimetic that localizes to bone, providing targeted therapy for skeletal metastasis. METHODS We investigated the mode of action of radium-223 dichloride using breast cancer cell, osteoclast, and osteoblast cultures as well as a mouse model of breas...

BACKGROUND The treatment of metastatic castration-resistant prostate cancer has changed with the introduction of radium-223, cabazitaxel, abiraterone and enzalutamide. To assess value for money, their cost effectiveness in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel from the Dutch societal perspective was investigated. METHODS A cost-effecti...

Purpose: Radium-223 dichloride (radium-223, Xofigo), a targeted alpha therapy, is currently used for the treatment of patients with castration-resistant prostate cancer (CRPC) with bone metastases. This study examines the mode-of-action and antitumor efficacy of radium-223 in two prostate cancer xenograft models.Experimental Design: Mice bearing intratibial LNCaP or LuCaP 58 tumors were randomi...

Radon concentrations were measured with long-term alpha-track radon detectors along with radon scout. Radon gas emanates from the radium content of terrestrial products, like tobacco leaves. Smoking materials contain, beside tobacco, many other additives that may also contain radium traces. These additives aim at exciting smoker’s feeling via chemical reactions, which may be disrupted by alpha ...

Naturally occurring radioactive materials (NORM) found in liquid wastes from hydraulic fracturing are an emerging environmental health concern. The heavily drilled Marcellus Shale, for example, contains isotopes of radium, polonium, and lead. However, the few studies that have focused on NORM in fracking wastewater (produced fluids) have reported on a single element—radium. In this issue of EHP...

Background: Health hazards associated with exposure due to the natural radioactivity which is a part of our physical environment are of great concern. In order to assess the risks associated with exposure due to the natural radioactivity in soil and building materials, extensive studies have been carried out all over the world. The most commonly encountered radionuclide’s are 238U, 2...

The determination of radium and/or uranium concentrations in natural waters is useful in a wide range of environmental studies. In this work, a low-background liquid scintillation system (Wallac, Quantulus 1220) was used to determine simultaneously 226Ra and uranium (total) activities in natural water samples. Sample preparation involved filtration and 1 : 10 concentration by evaporation. Then,...

This little volume deals briefly and completely with the properties of radium both from a therapeutic and physical point of view. Briefly dealing with the observations on the various phenomena which lead to the discovery of radium itself, the author passes to the physical properties of the element, and goes into the differentiation between the alpha, beta and gamma rays. The relationship existi...