Background: The present work aims to study the out-of-field photon calculation accuracy of a commercial treatment planning system (TPS), Oncentra, for three-dimensional conformal radiotherapy (3D-CRT) and intensity modulated radiation therapy (IMRT) treatment techniques from Elekta Synergy medical linear accelerator. Materials and Methods: Accuracy of individual out-of-field dose components was...

Reported doses of external beam radiotherapy and radioimmunotherapy (RIT) to produce equivalent therapeutic effects are inconsistent, with many proposed causes. Calculations of effective dose were performed for the case of LS174T human colon cancer xenografts, where a 60Co single fraction exposure (6 Gy) was matched with 131I-labeled 17-1A monoclonal antibody therapy (300 microCi injection, 19 ...

introduction: the complex geometry of breast and also lung and heart inhomogeneities near the planning target volume (ptv) result in perturbations in dose distribution. this problem can result in overdosage or underdosage in the match region of the three treatment fields. the purpose of this study is to create a homogeneous dose distribution in the match region between the supraclavicular and t...

background: breast cancer is the most frequently diagnosed cancer and the leading global cause of cancer death among women worldwide. radiotherapy plays a significant role in treatment of breast cancer and reduces locoregional recurrence and eventually improves survival. the treatment fields applied for breast cancer treatment include: tangential, axillary, supraclavicular and internal mammary ...

background: gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. objective: the aim of this study is to understand characteristics of secondary electrons generated from interaction of gold nanoparticles gnps with x-rays as a function of nanoparticle size and beam energy and ...

abstract background: accurate methods of radiation therapy dose calculation. there are different monte carlo codesfor simulation of photons, electrons and the coupled transport of electrons and photons. mcnpis a general purpose monte carlo code that can be used for electron, photon and coupledphoton-electron transport.monte carlo simulation of radiation transport is considered to be one of the ...

Dose painting radiotherapy is considered a promising radiotherapy technology that enables more targeted dose delivery to tumor rich regions while saving critical normal tissues. Obviously, dose painting planning would be more complicated and hard to be evaluated with current plan quality index systems that were developed under the paradigm of uniform dose prescription. In this study, we introdu...

Background: We have validated the monitor unit calculations from a commercially available treatment planning system (TPS) for three intensity modulated radiotherapy (IMRT) planning techniques for tangential breast irradiation by using ionization chamber measurements. Materials and Methods: Treatment plans were generated for forty-two breast patients by a forward planned field in field ...

In synchrotron stereotactic radiotherapy (SSR) the tumor is loaded with a high Z element, and exposed to monochromatic x-rays from a synchrotron source, in stereotactic conditions. The SSR treatment efficiency is related to the heavy element concentration achievable in the tumor, to the radiation energy, and the irradiation geometry [1,2]. The experimental dose verification of SSR in three dime...