Radiotherapy is the most common cancer treatment modality applying ionizing radiation. In majority of the cases, RT necessarily affects on normal tissues around the tumor. Silymarin is one of the most important chemical ingredients of the milk thistle. Silymarin composed of six flavonolignans that Silibinin, with 40-50%, is the most one. In view of the innumerable beneficial effects of silymari...

BACKGROUND Ionizing radiation (IR) initiates intracellular oxidative stress through enhanced formation of reactive oxygen species (ROS) that attack DNA leading to cell death. Because of the diversity of IR applied in medicine, agriculture, industry, and the growing threats of global terrorism, the acquisition of radioprotectors is an urgent need for the nation. However, the applicability of rad...

*Corresponding author: Dr. Jaimala sharma, Department of Zoology, University of Rajasthan, Jaipur-302055, India. E-mail: [email protected] Background: Radiotherapy is the main modality of cancer treatment. There are many chemical radioprotectors which unfortunately have lethal or toxic effect. Therefore the search is on to find out natural plant based radioprotectors. A well known medi...

AIM On the basis of the cytogenetic research, to develop and validate the strategy of the measures to prevent the stochastic effects of low-doses radiation on humans. METHODS Test system with human peripheral blood lymphocytes, metaphase analysis of chromosomal aberrations was used. Cells were cultured according to the standard procedures with modifications. The analysis of painted chromosome...

Studies on mechanisms of radioprotection are leading to a more rational use of protectors for different applications. In considering the feasibility of radioprotectors that act through various mechanisms, it is necessary to distinguish the application needed, e.g., protection against accidental external or internal exposures, acute high-dose radiation injury or low doses over a long period, hig...

This review gives a comparative evaluation of the radioprotective properties and the therapeutic index (TI) of radioprotectors from various pharmacological group in experiments on both small and large animals. It presents a hypothesis explaining the decrease in the TI of cystamine and 5-methoxytryptamine (mexamine), and the retention of that of α1-adrenomimetic indralin, and also compares the e...

Exposure to ionizing radiation is unavoidable for the many cancer patients that require radiotherapy as a component of their treatment. Radiation exposure also occurs from rare events, such as nuclear power plant malfunctions, terrorist attacks with “dirty bombs,” or detonation of nuclear weapons. The Chernobyl and Fukushima Daiichi disasters have demonstrated that the first responders to such ...

Bisbenzimidazoles have a broad spectrum of potential applications: radioprotectors, drug delivery vectors, antiviral agents, etc. At the same time, they seem to be promising fluorescent probes for radiation measurements. Therefore, in present work, response X-ray irradiation Hoechst 33258, one most widely known representatives bisbenzimidazole family, was studied first time. Irradiation dye per...