There is considerable interest in the deceleration of antiprotons for particle physics, atomic physics, gravitational experiments, PET radioisotope production, antiproton capture therapy, and deep-space spacecraft propellant. The only facility in the world presently capable of producing large uxes of usable antiprotons is the Fermi National Accelerator Laboratory (FNAL). Unfortunately, at this ...

Positron emission tomography (PET) imaging is based on detecting two time-coincident high-energy photons from the emission of a positron-emitting radioisotope. The physics of the emission, and the detection of the coincident photons, give PET imaging unique capabilities for both very high sensitivity and accurate estimation of the in vivo concentration of the radiotracer. PET imaging has been w...

Image guided technique is playing an increasingly important role in the investigation of the biodistribution and pharmacokinetics of drugs or drug delivery systems in various diseases, especially cancers. Besides anatomical imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), molecular imaging strategy including optical imaging, positron emission tomography (PE...

Thirty eight patients with known or suspected phaeochromocytoma were studied by radioisotope imaging after intravenous administration of iodine-131-meta- iodobenzylguanidine (131I- mIBG ), a radiopharmaceutical which has affinity for chromaffin tumours. Seventeen positive results (including one false positive) and 21 negative results (including two false negatives) were obtained. Clinical accur...

Aim: We present our experience about surgical resection of carotid body tumor (CBT) and to define the role of colour coded ultrasound (CCU) and of somatostatin receptor scintigraphy (SRS) with Indium-111-DTPA-pentreotide (Octreoscan®) using both planar and single photon emission tomography (SPECT) technique. Methods: Twenty-three patients suffering from 27 CBTs were treated from 1997 to 2014. P...

Ischemic Heart Disease (IHD) poses an important diagnostic problem. Clinical picture of the disease is often atypical. SPECT is one of the main diagnostic tools in ischemic heart disease. Radioisotope study evaluates distribution of a radiopharmaceutical agent in the heart through a series of scintigraphic images taken by an external gamma camera. This article discusses the technical aspects of...

A challenge in the development of novel 18F-labelled positron emission tomography (PET) imaging probes is identification metabolically stable sites to incorporate 18F radioisotope. Metabolic loss from PET vivo can lead misleading biodistribution data as displaced accumulate various tissues.In this study we report on vitro hepatic microsomal metabolism caffeine containing bifunctional compounds ...

University of Hull, UK Superparamagnetic iron oxide nanoparticles (SPIONs) are used as T2 magnetic resonance (MR) contrast agents. Nanorods (NRs) offer an interesting alternative to the more widely used nanospheres as they have shown to offer enhanced T2 relaxivities. The combination of MRI with nuclear imaging modalities such as positron emission tomography (PET) or single photon emission comp...

Radioisotope $^{52g}$Mn is of special interest for multimodal imaging. Using state-of-art nuclear reaction codes, we study the alternative route $^{nat}$V($\alpha$,x)$^{52g}$Mn in comparison with standard production routes based upon use chromium targets. The integral yields and contaminants have been evaluated. main outcome this investigation that contaminant isotope $^{54}$Mn expected to be l...