Radiation therapy is an important local cytotoxic modality for cancer treatment whose aim is to control the disease while minimising damage to normal tissue. The combination of different treatment modalities offers a more effective cure and reduction in normal tissue toxicity. However, the differences in genetic profiles can cause diverse treatment outcomes. Multidisciplinary research, where te...

A new expression for the radial dose distribution, tested against available data, and yielding good agreement with enzyme and virus cross sections, is used to calculate cellular inactivation cross sections from track theory models and parameters. We use a cellular model and radiosensitivity parameters, fitted to HILAC data 15 years ago, to represent mammalian cells irradiated at the UNILAC. The...

Purpose: Stereotactic body radiation therapy (SBRT) has emerged as a standard treatment modality for medically inoperable early-stage lung cancer patients. The aim of this paper is to calculate radiobiological parameters for a sample of 39 patients who underwent lung SBRT. Materials and Methods: For SBRT, a typical regimen of 50 Gy in 4 5 fractions results in local tumor control rates around 99...

Historically it has been shown repeatedly that single high doses of radiation do not allow a therapeutic differential between tumor and critical normal tissues but dose fractionation does. The purpose of conventional dose fractionation is to increase dose to the tumor while preserving normal tissue function. Tumors are generally irradiated with 2Gy dose per fraction delivered daily to a more or...

*Corresponding author: Prof. Satish Rao, BS, Division of Radiobiology & Toxicology, Manipal Life Sciences Center, Manipal University, Manipal 576 104, Karnataka, India. Fax: +91 82