نتایج جستجو برای: radioadaptive response

تعداد نتایج: 977319  

2013
Hongsheng Yu Ning Liu Hao Wang Qingjun Shang Peng Jiang Yuanmei Zhang

AIM OF THE STUDY We demonstrated stimulation of both erythrocyte immune function and superoxide dismutase activity in tumor-bearing mice in response to whole-body 75 mGy X-rays. In addition, we enhanced the chemotherapeutic effect by exposing tumor-bearing mice to low-dose radiation (LDR). This study aims to investigate the different responses of tumor cells and normal cells to LDR. MATERIAL ...

Journal: :Journal of radiation research 2005
Vincenzo Lanza Valeria Pretazzoli Gregorio Olivieri Giuseppe Pascarella Alessandro Panconesi Rodolfo Negri

We used cDNA microarray hybridization technology to monitor the transcriptional response of Human Umbilical Vein Endothelial (HUVEC) cells to x-rays doses ranging from 2 to 200 cGy. An early time window from irradiation (4h) was selected in order to minimize the effects of the cell cycle blockage eventually induced at high doses of irradiation. Three different gene-clustering algorithms have be...

Journal: :iranian journal of radiation research 0
s.m.j. mortazavi department of medical physics and medical engineering and the center for research in radiation sciences (crrs), shiraz university of medical sciences, shiraz, iran h. mozdarani department of medical genetics , school of medical sciences, tarbiat modares university, tehran, iran

some areas of ramsar, a city in northern iran are among the world’s wellknown inhabited areas with highest levels of natural radiation. annual exposure levels in these areas are up to 260 mgy y‐1 and the mean exposure rate is about 10 mgy y‐1 for a population of about 2000 residents. if elevated levels of natural radiation as high as a few hundred msv per year is detrimental to health and leads...

H. Mozdarani, S.M.J. Mortazavi,

Some Areas of Ramsar, a city in northern Iran are among the world’s wellknown inhabited areas with highest levels of natural radiation. Annual exposure levels in these areas are up to 260 mGy y‐1 and the mean exposure rate is about 10 mGy y‐1 for a population of about 2000 residents. If elevated levels of natural radiation as high as a few hundred mSv per year is detrimental to health and...

2017
V A Sergeeva E S Ershova N N Veiko E M Malinovskaya A A Kalyanov L V Kameneva S V Stukalov O A Dolgikh M S Konkova A V Ermakov V P Veiko V L Izhevskaya S I Kutsev S V Kostyuk

We have hypothesized that the adaptive response to low doses of ionizing radiation (IR) is mediated by oxidized cell-free DNA (cfDNA) fragments. Here, we summarize our experimental evidence for this model. Studies involving measurements of ROS, expression of the NOX (superoxide radical production), induction of apoptosis and DNA double-strand breaks, antiapoptotic gene expression and cell cycle...

2018
Juliana Vieira Dias Celine Gloaguen Dimitri Kereselidze Line Manens Karine Tack Teni G Ebrahimian

A central question in radiation protection research is whether low-dose and low-dose-rate (LDR) exposures to ionizing radiation play a role in progression of cardiovascular disease. The response of endothelial cells to different LDR exposures may help estimate risk of cardiovascular disease by providing the biological mechanism involved. We investigated the effect of chronic LDR radiation on fu...

2015
Jue Hou Fan Wang Peizhong Kong Peter K. N. Yu Hongzhi Wang Wei Han

Radioadaptive response (RAR) in mammalian cells refers to the phenomenon where a low-dose ionizing irradiation alters the gene expression profiles, and protects the cells from the detrimental effects of a subsequent high dose exposure. Despite the completion of numerous experimental studies on RAR, the underlying mechanism has remained unclear. In this study, we aimed to have a comprehensive in...

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