We report radiation necrosis as the first manifestation of a germline mutation in telomerase. A 60-year-old woman presented with defective wound healing after multiple surgical explorations of the chest wall to exclude breast cancer recurrence. At age 42, she received a diagnosis of stage I estrogen receptor–positive left breast infiltrating ductal carcinoma on routine mammography. Lumpectomy w...

Glioblastoma Multiforme (GBM) is a highly aggressive brain tumor originating from glial cells that subset of higher-grade gliomas (HGG). Given the extreme malignancy GBM and HGG, radiotherapy often used to shrink inhibit cell function. Despite use radiotherapy, recurrence rates remain high, complications, such as radiation necrosis, can arise. Recurrent necrosis are nearly indistinguishable usi...

the Cochrane review, with its emphasis on randomized controlled trials, does not advocate universal application of HBO2 to delayed radiation injuries. In the United States, third-party insurance entities will frequently reimburse for this application, but often a formal appeal will be required to obtain payment. In informal surveys of HBO2 practitioners at continuing medical education meetings ...

OBJECT Following stereotactic radiosurgery (SRS), we examined how to differentiate radiation necrosis from recurrent malignant glioma using positron emission tomography (PET) with 11C-methionine (Met). METHODS Met-PET scans were obtained from 11 adult cases of recurrent malignant glioma or radiation injury, suspected on the basis of magnetic resonance images (MRI). Patients had previously bee...

Abstract Radiation induced pseudoprogression (PsP) of brain tumors is defined radiologically as new or enlarging areas non-tumor magnetic resonance imaging (MRI) contrast enhancement developing within the initial 3-6 months after completing radiation. Distinguishing PsP from genuine tumor progression utmost importance in deciding clinical course a patient. Although it typically diagnosed radiol...

A patient presented with symptoms and signs of raised intracranial pressure and increasing focal deficit 13 months after stereotactic radiosurgical treatment of an arteriovenous malformation (AVM). Computed Tomography (CT) showed a mass lesion at the site of the previous abnormality typical of radiation necrosis, but with features identical to those of a malignant neoplasm. Biopsy confirmed cer...

OBJECTIVE The aim of the paper was to investigate the recurrence and its causes of radiation brain necrosis following bevacizumab discontinuation. METHODS This study included 14 patients with radiation brain necrosis (confirmed through imaging) after stereotactic radiotherapy for a primary or metastatic brain tumor and who received bevacizumab treatment from June 2011 through December 2014. T...

PURPOSE To determine whether radiation necrosis can be differentiated from residual/recurrent tumor by proton MR spectroscopy. METHODS We studied the effects of interstitial brachytherapy on the brains of healthy monkeys and in humans with glioblastoma multiforme. The effects of radiation therapy on normal brain tissue in monkeys were assessed with sequential proton MR spectroscopic studies 1...

BACKGROUND AND PURPOSE MR image-guided gamma knife radiosurgery is often used to treat intra-axial metastatic neoplasms. Following treatment, it is often difficult to determine whether a progressively enhancing lesion is due to metastatic tumor recurrence or radiation necrosis. The purpose of our study was to determine whether relative cerebral blood volume (rCBV), relative peak height (rPH), a...