نتایج جستجو برای: racemic phenylalanine methyl ester

تعداد نتایج: 147397  

Journal: :Metal-Based Drugs 1996
M. C. Miller A. Sood B. F. Spielvogel R. P. Shrewsbury I. H. Hall

The metabolites of N-[(trimethylamineboryl)-carbonyl]-L-phenylalanine methyl ester 1 proved to be active in a number of pharmacological screens where the parent had previously demonstrated potent activity. The proposed metabolites demonstrated significant activity as cytotoxic, hypolipidemic, and anti-inflammatory agents. In cytotoxicity screens several of the proposed metabolites afforded bett...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
David A Boudreaux Tushar K Maiti Christopher W Davies Chittaranjan Das

Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a Parkinson disease-associated, putative cysteine protease found abundantly and selectively expressed in neurons. The crystal structure of apo UCHL1 showed that the active-site residues are not aligned in a canonical form, with the nucleophilic cysteine being 7.7 A from the general base histidine, an arrangement consistent with an inactive form...

Journal: :Proteins 1992
I L Karle J L Flippen-Anderson M Sukumar P Balaram

The packing of peptide helices in crystals of the leucine-rich decapeptide Boc-Aib-Leu-Aib-Aib-Leu-Leu-Leu-Aib-Leu-Aib-OMe provides an example of ladder-like leucylleucyl interactions between neighboring molecules. The peptide molecule forms a helix with five 5----1 hydrogen bonds and two 4----1 hydrogen bonds near the C terminus. Three head-to-tail NH ... O = C hydrogen bonds between helices f...

2008
Mitsunobu Doi Yuko Ichimiya Akiko Asano

The conformation of the title tripeptide methyl ester hydro-chloride monohydrate, 1-[2-(methoxycarbonylmethylaminocarbonyl)pyrrolidin-1-ylcarbonyl]-2-phenylethanaminium chloride monohydrate, C(17)H(24)N(3)O(4) (+)·Cl(-)·H(2)O, is extended, but the structure cannot be classified as any typical secondary structure. Interactions through water molecules and chloride ions were formed, in addition to...

Journal: :Chemical communications 2015
Fanpeng Kong Xiaoyue Meng Ranran Chu Kehua Xu Bo Tang

Based on a unique elimination reaction prompted by the iodide ion, a novel turn-on fluorescence probe (HCy-OMe-Br) has been developed for the first time. The probe emits in the near infrared region with a large Stokes shift, and can respond rapidly to iodide with high selectivity and sensitivity.

Azam Pirkarami, Leila Fereidooni, R. Khalilnezhad

This experiment is an investigation of used cooking oil as a sustainable and renewable resource for methyl ester production. with more than 95.5% production yield, thermally activated hydrated cement has been carefully discussed as a catalyst in the transesterification of used cooking oil into methyl ester to use waste cement as a heterogeneous catalyst for methyl ester production through elect...

Journal: :Acta Chemica Scandinavica 1956

Journal: :The Journal of biological chemistry 1969
A Himoe K G Brandt R J DeSa G P Hess

Pre-steady state kinetic parameters pertaining to chymotrppsin-catalyzed hydrolysis of specific substrate esters can be obtained from measurements of the displacement of the competitive inhibitor proflavin from enzyme by substrate. This method, which was previously used in experiments with specific substrate amides, has now been applied to the investigation of N-acetyl-L-phenylalanine methyl es...

Journal: :asia pacific journal of medical toxicology 0
rachid el-jaoudi laboratory of pharmacology and toxicology, faculty of medicine and pharmacy, rabat, morocco luc humbert laboratory of toxicology and genopathy, center of biology and pathology, lille, france frederique grisel waters corporation, european headquarters and waters s.a.s., guyancourt, france yahya cherrah laboratory of pharmacology and toxicology, faculty of medicine and pharmacy, rabat, morocco daniel mathieu emergency department, calmette hospital, lille, france michelle lhermitte laboratory of toxicology and genopathy, center of biology and pathology, lille, france

background: cocaine poisoning is known for causing severe clinical effects such as tachycardia, hypertension, agitation and confusion. absence of clinical manifestations in cocaine poisoning is unusual. case report: a 26-year old man, known to be a cocaine addict, declared that he was forced by cocaine dealers to swallow many tablets of cocaine, six hours prior to admission to emergency departm...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1976
P G Richman J S Fruton

Treatment of swine pepsin with acetylimidazole to acetylate approximately five of its 16 tyrosyl residues causes a significant enhancement of catalytic efficiency (kcat/Km) toward substrates such as dansyl-glycyl-glycyl-L-phenylalanyl-L-phenylalanine 3-(4-pyridyl)propyl ester and benzyloxy-carbonyl-(glycyl)n-p-nitroLphenylalnyl-Lphenylalanyl-L-tyrosine (where n = 0, 1,2). Stopped-flow kinetic s...

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