AIMS Heart failure remains a leading cause of morbidity, hospitalizations, and deaths. We previously showed that overexpression of the enzyme ribonucleotide reductase (RNR) in cardiomyocytes increased levels of the myosin activator, 2-deoxy-ATP, catalysed enhanced contraction, and improved cardiac performance in rodent hearts. Here we used a swine model of myocardial infarction (MI) to test pre...

This study aimed to explore the dynamic variations of rumen fermentation characteristics and bacterial community composition during a 24 h in vitro fermentation. A total twenty-three samples were collected from original fluid (ORF, n = 3), at 12 (R12, 10), (R24, 10). Results showed that gas production, concentrations microbial crude protein, ammonia nitrogen, individual volatile fatty acids (VF...

Discharge gas temperature value is an indicator of compressor safe operating conditions, particularly on R12 and R502 commercial applications. These refrigerants will be replaced very soon by R134a and R22 respectively, also if R22 is not considered a final solution. High discharge temperatures are typical in LBP-R22 hermetic compressors operating at low evaporating temperature as low as -40"C;...

A quadratic polynomial differential system can be identified with a single point of R12 through the coefficients. Using the algebraic invariant theory we classify all the quadratic polynomial differential systems of R12 having an integrable saddle. We show that there are only 47 topologically different phase portraits in the Poincaré disc associated to this family of quadratic systems up to a r...

Using a repeat sales data set, this paper tests whether a single small seller can influence the selling price of their house. We find that this influence exists and that it dominates the influence of commonly-used market conditions. Since the estimated magnitude of this effect is much higher than expected, we verify the estimate using several supplementary tests. JEL: C78, D80, R21, R31

To approach the complete basis set limit of the "gold-standard" coupled-cluster singles and doubles plus perturbative triples [CCSD(T)] method, we extend the recently proposed perturbative explicitly correlated coupled-cluster singles and doubles method, CCSD(2)(R12) [E. F. Valeev, Phys. Chem. Chem. Phys. 8, 106 (2008)], to account for the effect of connected three-electron correlations. The na...