5-Fluorouracil (5-FU) chemotherapy is the first choice treatment for advanced hepatocellular carcinoma (HCC), and resistance is the major obstacle to successful treatment. Recent studies have reported that epithelial-to-mesenchymal transition (EMT) is associated with chemoresistance in cancers. We speculated that EMT and 5-FU metabolism are relate...

Abstract: We suggest a suite of NGST studies aimed at the detection and characterization of planets over a range of mass, age, stellar spectral type, and physical separation from their central stars. The results of these studies will constitute fundamental steps toward an understanding of the origin of planets and life in the universe, and, in particular, will lay the groundwork for future NASA...

BACKGROUND Little is known about asthma trend in Morocco, particularly in early childhood. Furthermore, when dealing with asthma related environmental risk factors in Morocco, decision-making focus is in one region R9, while 16 regions make up the country. This work aims at studying 9-year trends in consultations for asthma in under-5 children in the 16 individual regions with respect to area a...

Gymnastics floor exercises are composed of a set of four to five successive acrobatic jumps usually called a "series". The aims of the study were: 1) to relate the acrobatic gymnastics performance of these series with a repeated jumps test of similar duration (R60), 2) to study the relation between R60 and physiological parameters (heart rate and blood lactate), and the performance obtained in ...

Four ryanodine receptor type 1 and 2 chimeras (R4, R9, R10, and R16) and their respective wild-type ryanodine receptors (type 1 and 2; wtRyR1 and wtRyR2) were expressed in dyspedic 1B5 to identify possible negative regulatory modules of the Ca2+ release channel that are under the influence of the dihydropyridine receptor (DHPR). Responses of intact 1B5 myotubes expressing each construct to caff...

BACKGROUND There is a paucity of data on lung physiology in late-preterm children, who may be exposed to a risk of decline in lung function during childhood. In this study, we evaluated lung function in preschool children born late preterm using impulse oscillometry (IOS), and compared the results with those obtained in healthy term-born children. METHODS Children between 3 and 7 years of age...

Abstract Even though the management operation guidelines have been determined, optimal of Citarum Cascade Reservoir has not yet achieved. Optimal cascade reservoirs in an integrated manner is difficult to be carried out due complex operating procedures and high uncertainty hydrological components. So, research on each reservoir considering discharge forecasting model as input (Qin) was proposed...

Road vehicles are a key part of the climate change challenge, representing both an important source of petroleum demand and greenhouse gas (GHG) emissions worldwide. In the United States, light-duty vehicles (LDVs, i.e., cars and light trucks) alone account for 43% of petroleum demand and 23% of GHG emissions, when fuel production is considered [MacKenzie, 2013]. The United States, Europe, Chin...

the presence of tribolium castaneum (herbst) in a stored food results in contamination and substantial economic damage due to loss of the products and a decrease in nutritional value. this study was conducted to determine the pesticidal and pest repellent activities of roots of laportea crenulata gaud. against t. castaneum. pesticidal activity was determined using surface film method, whereas, ...