Introduction: Patients (pts) with diffuse large B-cell lymphoma (DLBCL) who relapse after stem cell transplant or chimeric antigen receptor therapy are refractory to second-line have poor prognosis and few treatment options (Chow et al., 2019). For these pts, long-term disease control manageable toxicity is the goal. Loncastuximab tesirine (loncastuximab tesirine-lpyl; Lonca), an anti-CD19 anti...

Introduction: Camidanlumab tesirine (Cami) is an antibody-drug conjugate comprising a human IgG1 anti-CD25 monoclonal antibody conjugated to pyrrolobenzodiazepine (PBD) dimer warhead. Cami has demonstrated encouraging antitumor activity and manageable toxicity in Ph 1 trial lymphomas, particularly R/R cHL. Here we present preliminary results of 2 study monotherapy pts with Methods: Pts cHL ≥3 p...

Introduction: Brexu-cel is a CAR T-cell therapy approved for adult patients (pts) with r/r MCL. In 3-year follow-up of ZUMA-2 (Wang et al. 2022), ORR was 91% (CR, 68%). Median DOR, PFS, and OS were 28.2, 25.8, 46.6 mo, respectively. Here, we describe real-world outcomes brexu-cel analyzed by prior receipt BTK inhibitor (BTKi), bendamustine, or autoHCT, 1–2 versus ≥3 lines (L) therapy. Methods: ...

Introduction: Despite progress in treating LBCL, approximately 50% to 60% of pts will either not achieve a complete response (CR) or relapse after current first- second-line therapy. Autologous anti-CD19 chimeric antigen receptor (CAR) T cells have revolutionized the care with r/r LBCL; however, patient-specific manufacturing processes and long wait times prevent their broad use many who would ...

2002. Special issue on expression profiling within the central nervous system. Neurochem Res 27: (10) 2002. Special issue: Comparative genomics. Comp Biochem Physiol B Biochem Mol Biol 133: (4) Awadalla P. 2003. The evolutionary genomics of pathogen recombination. Nat Rev Genet 4: (1) 50. Bacarese-Hamilton T, Bistoni F, Crisanti A. 2002. Protein microarrays: From serodiagnosis to whole proteome...

extended abstract 1. introduction badi'ozaman and hariri maqameh are among the very important literary prose genres, which first emerged during the abbasid period. such short stories serve different literary purposes and reflect different social, economic and cultural aspects of their time. for this reason, some researchers have largely investigated it. the prose literary language of these work...

|Full Text: PDF (444 KB) 6. A Communication Perspective on Automatic Text Categorization Capdevila, M.; Florez, O.W.M. Knowledge and Data Engineering, IEEE Transactions on Volume 21, Issue 7, Date: July 2009, Pages: 1027-1041 Digital Object Identifier 10.1109/TKDE.2009.22 Abstract |Full Text: PDF (2515 KB) 7. A Bio-Inspired Active Radio-Frequency Silicon Cochlea Mandal, S.; Zhak, S.M.; Sarpeshk...