BACKGROUND We evaluated the effectiveness of a computer clinical decision support system (CDSS) for reducing the risk of QT interval prolongation in hospitalized patients. METHODS AND RESULTS We evaluated 2400 patients admitted to cardiac care units at an urban academic medical center. A CDSS incorporating a validated risk score for QTc prolongation was developed and implemented using informa...

We performed this study to determine whether electrocardiographic corrected QT (QTc) interval predicts alterations in sympathovagal balance during orthostatic intolerance (OI). We reviewed 1,368 patients presenting with symptoms suggestive of OI who underwent electrocardiography and composite autonomic function tests (AFTs). Patients with a positive response to the head-up tilt test were classi...

Objectives: The aim of this study was to evaluate the prevalence and the risk factors of prolonged QTc interval among Egyptian patients with type 2 diabetes. Patients and methods: We enrolled in this cross-sectional study from June 2011 to December 2015, a total of 220 patients (108 male & 112 female) with mean age 50.42± 7.453years diagnosed with type 2 DM. Results: In this study, we found (33...

OBJECTIVE Heart rate-corrected QT (QTc) interval is associated with mortality in the general population, but this association is less clear in individuals with type 2 diabetes. We assessed the association of QTc interval with all-cause and cardiovascular disease (CVD) mortality in the Diabetes Heart Study. RESEARCH DESIGN AND METHODS We studied 1,020 participants with type 2 diabetes (83% Eur...

BACKGROUND HD has been reported to determine an increase in QTc interval and QTc dispersion (QT(max)-QT(min))-risk factors that predispose to severe ventricular arrhythmias and sudden death. However, most studies have included end-stage renal disease (ESRD) patients with significant heart pathology. We therefore aimed to study the impact of a single HD session in subjects without manifest cardi...

BACKGROUND AND PURPOSE Sudden cardiac death is one of the leading causes of death in patients with myotonic dystrophy type 1 (DM1). It has been proposed that a prolonged QT interval is associated with sudden cardiac death in several neurological diseases, including multiple system atrophy, idiopathic Parkinson's disease, and diabetic autonomic neuropathy. However, analyses of the corrected QT (...

Background: To the best of our knowledge, there are studies related to QT and QTc interval in patients with hypocalcemia, but no evaluating T wave peak end (Tp-e interval), Tp-e/QT Tp-e/QTc ratios used evaluate cardiac arrhythmia risk ventricular repolarization changes rates. Objectives: Therefore, we aimed investigate whether is a change Tp-e interval, hypocalcemia. Methods: Retrospectively, 2...

Sir, Ketamine is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. It is widely used as a dissociative anesthetic and is also used as an adjunct in pain management, particularly in opioid-tolerant patients. It blocks calcium channels and depresses sodium channel function as well as having anticholinergic effects. It inhibits the re-uptake of the catecholamines and may hav...