Background Stroke is on the rise in India with great impact on morbidity and mortality. One of the factors associated with poor outcome among stroke patients are some electrocardiographic (ECG) changes resulting from massive autonomic discharge that interferes with cardiac autonomic control. Objective To determine ECG changes and three months outcomes of patients admitted with new onset stroke ...

BACKGROUND Recent molecular biological investigations have identified abnormal genes in familial forms of long QT syndrome, but in bradycardia dependent acquired long QT syndrome, no such genetic abnormality has yet been identified. OBJECTIVE To investigate the relation between the responses of QT interval to pacing change and to disopyramide. METHODS This study included 13 patients with br...

Thorough QT/QTc studies have become an integral part of early drug development programs, with major clinical and regulatory implications. This analysis expands on existing pharmacodynamic models of QT interval analysis by incorporating the influence of glycemic changes on the QT interval in a semimechanistic manner. A total of 21 healthy subjects enrolled in an open-label phase 1 pilot study an...

The drug-induced QT prolongation predisposes to development of torsades de pointes (TdP) ventricular tachycardia and sudden death. The association between specific drug and development of TdP is difficult to document, therefore, QT prolongation is considered as a surrogate marker of the proarrhythmia risk. Most of the drugs prolong QT interval usually by blocking the potassium IKr current or al...

BACKGROUND AND OBJECTIVES The importance of minimizing the exaggerated sympatho-adrenergic responses and QT interval and QT interval dispersion changes that may develop due to laryngoscopy and tracheal intubation during anesthesia induction in the hypertensive patients is clear. Esmolol decreases the hemodynamic response to laryngoscopy and intubation. However, the effect of esmolol in decreasi...

Background: To the best of our knowledge, there are studies related to QT and QTc interval in patients with hypocalcemia, but no evaluating T wave peak end (Tp-e interval), Tp-e/QT Tp-e/QTc ratios used evaluate cardiac arrhythmia risk ventricular repolarization changes rates. Objectives: Therefore, we aimed investigate whether is a change Tp-e interval, hypocalcemia. Methods: Retrospectively, 2...

A new approach was developed to evaluate the QT interval response to RR interval changes in 24-hour ambulatory recordings, regarding different settings of the recording. First, a method was proposed to automatically identify beat positions in the following two situations: a) preceded by stable heart rate, b) after a sharp change in rate. Also, the evaluation across the complete recording was co...

BACKGROUND Limited data are available on the effects of a ketogenic diet on dispersion duration of P-wave and QT-interval measures in children. We searched for the changes in these measures with serial electrocardiograms in patients treated with a ketogenic diet. METHODS Twenty-five drug-resistant patients with epilepsy treated with a ketogenic diet were enrolled in this study. Electrocardiog...

The time lag of the QT interval adaptation to heart rate changes (QT/RR hysteresis) was studied in 40 healthy subjects (18 females; mean age, 30.4+/-8.1 yr) with 3 separate daytime (>13 h) 12-lead electrocardiograms (ECG) in each subject. In each recording, 330 individual 10-s ECG segments were measured, including 100 segments preceded by 2 min of heart rate varying greater than +/-2 beats/min....