Soldiers are exposed to multiple stress conditions adverse psychological, physico-chemical and environmental conditions during warfare which can result in significant physical and chemical alterations in the biological system. The effects of carbamate (pyridostigmine bromide, PB) pretreatment prior to physiological stress and organophosphorous compound, DFP (diisopropylfluorophosphate) exposure...

Twenty-seven patients with myasthenia gravis have been treated with azathioprine in conjunction with pyridostigmine and prednisolone for a total of 138 patient years. Side effects necessitated discontinuation of treatment in only four patients. Treatment with azathioprine was associated with marked clinical improvement in all the remaining 23 patients, resulting in reduction in the dose of pyri...

An anaphylactic reaction during general anesthesia may cause fatal complications. Perioperative anaphylaxis can occur in response to different medications. To our knowledge, pyridostigmine or combination of pyridostigmine with glycopyrrolate-induced anaphylactic reaction during general anesthesia has not been reported. We report a case of a suspected anaphylactic reaction to these drugs. To red...

A composite polymer surface coated on a tin oxide offers dramatic improvement in the stability and sensitivity of voltammetric measurement of pyridostigmine bromide as compared to individual tin oxide, polyaniline or polypyrrole coated electrode. A linear current response was achieved with a detection limit of 1x10 M. The stability and morphology of the polymer surfaces were determined by therm...

background: the majority of dyspeptic patients do not have identifiable disease, which is also known as functional dyspepsia. the therapeutic approach to patients with functional dyspepsia is still a matter of debate; prokinetic agents are commonly used for symptom relief. this study aims to evaluate the efficacy of domperidone and pyridostigmine (an inhibitor of cholinesterase) in patients wit...

Full toxicologic profiles of chemical mixtures, including dose-response extrapolations to realistic exposures, is a prohibitive analytical problem, even for a restricted class of chemicals. We present an approach to probing in vivo interactions of pesticide mixtures at relevant low doses using a monitor compound to report the response of biochemical pathways shared by mixture components. We use...

BACKGROUND Postural tachycardia syndrome (POTS) induces disabling chronic orthostatic intolerance notable for an excessive increase in heart rate that occurs on standing. Many current therapeutic strategies focus on sympatholysis, but the alternative strategy of enhancing cardiovagal tone has not been studied. The objective of this study was to test the hypothesis that acetylcholinesterase inhi...

Background: Botulinum toxin (BoNT) or Botox injections are popular non-surgical and non-invasive option to optimize change an individual’s facial appearance achieve rejuvenation. Pyridostigmine is acetylcholinesterase inhibitor important in clinical practice. This study evaluated the toxic effect of BoNT demonstrate efficacy anticholinesterase pyridostigmine....

Pyridostigmine bromide (PB) is a reversible cholinesterase inhibitor. The aim of this study was to determine the effect of orally administration of single dose sustained-released tablet of pyridostigmine bromide (PBSR) on the frequency domain indices of heart rate variability (HRV). Thirty-two healthy young men were participated in this study. They were divided into 2 groups; the pyridostigmine...

Pyridostigmine bromide (PB) is a reversible cholinesterase inhibitor. The aim of this study was to determine the effect of orally administration of single dose sustained-released tablet of pyridostigmine bromide (PBSR) on the frequency domain indices of heart rate variability (HRV). Thirty-two healthy young men were participated in this study. They were divided into 2 groups; the pyridostigmine...