PURPOSE To describe abnormal white matter in the brain on MR in Wilson disease and to compare with anatomic location of white matter tracts. METHODS Forty-six patients with Wilson disease were examined. Axial T1-weighted inversion-recovery, axial T2-weighted spin-echo, and coronal T2*-weighted gradient-echo MR images were performed. Imaging studies were compared with clinical data. RESULTS ...

A 67-year-old man with chronic lymphatic leukemia presented with a 1-month history of subacute right hemiparesis with right central facial palsy and right extensor plantar response, but without sensory deficits. MRI showed hyperintense lesions along the pyramidal tracts on T2-weighted and FLAIR images (figure). CSF PCR revealed JC virus infection leading to the diagnosis multifocal leukoencepha...

A 73-year-old diabetic man treated with oral hypoglycemic agents presented with dysarthia. He was alert and could obey simple verbal and written commands. His dysarthria was too severe to understand. Muscle tone of his legs was increased. Deep tendon reflexes were generally decreased without pathological reflex or clonus. The blood glucose level was 44 mg/dL. Diffusion-weighted MR imaging (DWI)...

A novel MRI method--diffusion tensor imaging--was used to compare the integrity of several white matter fibre tracts in patients with probable Alzheimer's disease. Relative to normal controls, patients with probable Alzheimer's disease showed a highly significant reduction in the integrity of the association white matter fibre tracts, such as the splenium of the corpus callosum, superior longit...

A 41 year old man with parkinsonism and pyramidal signs is described. He was non-responsive to levodopa and dopamine receptor agonists but dramatically responded to trihexyphenidyl. In this patient, brain MRI showed bilateral hyperintensities along the corticospinal tracts on T2 weighted images. PET studies showed a decrease in (18)F-6-fluorodopa uptake in the putamen contralateral to the more ...

Following a brief review of the concept of extrapyramidal system, clinical and anatomic evidence is presented against its relative prominence in man. It is proposed that the greatest part of those structures traditionally labeled as extrapyramidal effects its respective functional activities by way of the pyramidal tracts themselves. Such structures, centered around the basal nuclei, the cerebe...

We present the MR imaging findings in four patients (two pairs of siblings from two unrelated families) with adult Krabbe disease. In the first family, clinical presentation mimicked familial spastic paraplegia. Their MR images showed selective, increased signal intensity on T2-weighted sequences along the corticospinal tracts, most prominently in the proband and barely detectable in her brothe...

Previous work has identified axonal outgrowth and/or guidance defects in the brain and spinal cord of prenatal Frizzled3 (Fz3)(-/-) mice. To systematically explore the axonal defects in Fz3(-/-) mice and to compare techniques for the global assessment of axon tracts in the developing mouse, we have analyzed wild-type and Fz3(-/-) brains using (1) diffusion tensor magnetic resonance imaging (muD...

OBJECT Intrinsic diffuse brainstem tumors and demyelinating diseases primarily affecting the brainstem can share common clinical and radiological features, sometimes making the diagnosis difficult especially at the time of first clinical presentation. To explore the potential usefulness of new MRI sequences in particular diffusion tensor imaging fiber tracking in differentiating these two patho...