BACKGROUND AND OBJECTIVES Different experimental models have been used to illustrate hemodynamic and metabolic changes during hemorrhagic shock. This study aimed at observing hemodynamic and metabolic behaviors during a sequential and progressive model of hemorrhagic shock in dogs to determine which indices are earlier changed. METHODS The study involved 13 dogs under total intravenous anesth...

BACKGROUND Measures assessing quality of life (QOL) in patients participating in comprehensive cardiac rehabilitation (CCR) have not been established in Japan. METHODS AND RESULTS To compare different types of QOL scales and to determine the impact of CCR on QOL in Japanese cardiac patients, 5 different types of questionnaires were assessed in 44 patients participating in CCR after acute myoc...

OBJECTIVE To examine the relation between longitudinal left ventricular function assessed by tissue Doppler imaging (TDi) and exercise capacity in heart failure. SUBJECTS 153 patients with chronic heart failure from left ventricular systolic dysfunction (ejection fraction < 45%) and 87 age and sex matched controls. METHODS Echocardiography was used to measure conventional indices of left ve...

OBJECTIVES Because the muscle response to incremental exercise is not well documented in patients suffering from chronic fatigue syndrome (CFS), we combined electrophysiological (compound-evoked muscle action potential, M wave), and biochemical (lactic acid production, oxidative stress) measurements to assess any muscle dysfunction in response to a routine cycling exercise. DESIGN This case-c...

Abstract Introduction Mavacamten, a first-in-class selective inhibitor of cardiac myosin, was demonstrated in EXPLORER-HCM (NCT03470545) to be superior placebo achieving primary endpoint either (1) ≥1.5 mL/kg/min increase peak oxygen consumption (pVO2) and at least one New York Heart Association (NYHA) class reduction, or (2) ≥3.0 pVO2 without NYHA worsening, adults with obstructive hypertrophi...

Abstract Introduction Severe aortic stenosis (AS) and mitral regurgitation (MR) often coexist. Transcatheter valve implantation (TAVI) is becoming widely used for the treatment of patients (pts) with symptomatic severe AS. However, conflicting data reside concerning impact MR on outcomes after TAVI. Also, very few exist regarding benefits a cardiac rehabilitation program (CRP) following TAVI in...

Abstract Background Exercise ventilation inefficiency, i.e. increase slope of the relationship (VE) vs carbon dioxide (VCO2) is a key prognostic indicator in heart failure (HF). Many determinants have been identified primarily related to left and impaired reflexogenic control VE. In parallel, severity tricuspid regurgitation (TR) at rest increasingly recognized as an important determinant funct...

Abstract Introduction Cardiopulmonary exercise testing (CPET) is recommended in patients with heart failure (HF) to optimize prescription and as part of the evaluation for transplantation. Hemodynamic gain index (HGI) derived from CPET has been proposed a new marker risk stratification general population cohorts. Purpose We aimed evaluate prognostic value HGI HF. Methods conducted single-centre...

Abstract Objectives the physio-pathological role of morphological ventricular dominance (left, FSLV; right, FSRV), and hemodynamic contribute an accessory chamber (AVC), in patients with functional single ventricle (FSV) after Fontan operation are still uncertain due to conflicting data. We analyzed a cohort assess correlate such anatomical features late clinical outcomes. Methods enrolled all ...