Looking up – you realize that one of the twelve light bulbs of your living room chandelier has to be replaced. You turn electricity off, move a table to the center of the room, put a chair on top of the table and, new bulb in hand, you climb up on top of the chair. As you reach the chandelier, you notice that. . . all bulbs look alike and that you have forgotten which bulb needed to be changed....

W orldwide, noncommunicable diseases are the dominant cause of death, with atherosclerotic cardiovascular disease a major contributor. 1 These deaths are spread across high-to low-income countries, with ≈1 in 3 of all cardiovas-cular disease deaths occurring in individuals aged <70 years, amounting to an estimated 6 million cases annually. 1 Analyses in many countries have shown that both an im...

We derive a simple relationship between the values and exercise boundaries of American puts and calls. The relationship holds for options with the same \moneyness", although the absolute level of the strike price and underlying may di er. The result holds in both the Black Scholes model and in a more general di usion setting. We thank Neil Chriss, the editor, and two anonymous referees for thei...

We present a new put option where the holder enjoys the early exercise feature of American options whereupon his payoff (deliverable immediately) is the ‘best prediction’ of the European payoff under the hypothesis that the true drift of the stock price equals a contract drift. Inherent in this is a protection feature which is key to the British put option. Should the option holder believe the ...

D NA double strand breaks (DSBs) interrupt the integrity of the chromosomal fi ber, but that does not mean the damaged chromatin is free to move around, show Kruhlak et al. on page < A r t R e f v o l = " 1 7 2 " I s s = " 6 " > 823< / A r t R e f >. The team used correlative fl uorescence and energy-fi ltering microscopy to watch what happens to chromatin after DSBs occur. The technique measur...

Pygo2 opens chromatin and cycles cells B y spreading an active chromatin state, Pygo2 prompts the proliferation of mammary gland progenitor cells, report Gu et al. The fl y version of Pygo2, Pygopus, is essential for Wg signaling. But the relationship between mammalian Wg (Wnt) and Pygo2 is less clear. Pygo2 is necessary for the development of a number of tissues, but in the two best studied—ey...

s. The third ALR goal of using research to inform policy and practice was achieved by having policy makers on the program, attracting 33 % of attendees from policy, practice, and advocacy backgrounds and giving the annual Translating Research to Policy Award. A panel presentation featured multi-sector childhood obesity and active living programs that use research and evaluation to guide their e...