Psoriasis is a common chronic skin disorder characterized by abnormal epidermal proliferation and infiltration of inflammatory cells which affects approximately 2-4 % of the general population [1-3]. Psoriasis Vulgaris (PV), the most common clinical variant, comprises 85 to 90% of all patients with psoriasis. This disease is usually manifested as well-demarcated erythematous oval plaques with s...

M.J. Korstanje, Department of Dermatology, Academic Hospital Maastricht, PO Box 1918, NL–6201 BX Maastricht (The Netherlands) The effectiveness of ciclosporin (CsA) in severe plaque psoriasis is established [1. 2]. However. CsA may not be randomly used in clinical practice because of its side effects, which include hepatotoxicity. acute and chronic nephrotoxicity, hirsutism. hypertension and to...

GPP: generalized pustular psoriasis IL-36RN: interleukin-36 receptor antagonist PV: psoriasis vulgaris INTRODUCTION Generalized pustular psoriasis (GPP) is a rare but serious inflammatory skin disease that may be caused by deficiency of interleukin-36 receptor antagonist in which there is presence of homozygous or compound heterozygous mutations of the IL-36RN gene. Most GPP cases are sporadic,...

© 2013 The Authors. doi: 10.2340/00015555-1463 Journal Compilation © 2013 Acta Dermato-Venereologica. ISSN 0001-5555 Infliximab, a chimeric monoclonal immunoglobulin G (IgG) antibody against tumour necrosis factor alpha (TNF-α), is effective in patients with psoriasis, including pustular psoriasis and psoriatic arthritis (1). Infliximab results in a Psoriasis Area Sensitivity Index (PASI) 75 re...

Results We found IL36RN recessive mutations in patients with GPP (7/84) and localised pustular psoriasis (2/9 cases of Acrodermatitis Continua of Hallopeau and 3/139 cases of plamar-plantar pustulosis), but not among PV cases. Of note, we also identified several affected individuals who carried a single heterozygous mutation. In fact, we uncovered a significant enrichment of heterozygous IL36RN...

Impetigo herpetiformis is a rare life threatening pustular dermatoses of pregnancy. The aetiology is unclear but is usually steroid responsive. A case of impetigo herpetiformis in a multiparous 43 year old Iban lady in her 29 weeks of gestation is presented. She responded to topical corticosteroids initially but recurred postpartum, only to respond to Acitretin. Egyptian Dermatology Online Jour...

Psoriasis is a common inflammatory, hyperproliferative skin disorder that affects 1% to 2% of the world population. The clinical diagnosis of psoriasis is relatively easy, especially when the lesions consist of erythematous, silvery white scaly, sharply demarcated, indurated plaques. Psoriasis is a chronic dermatosis of genetic origin, often precipitated by an event such as an infection, an inj...

OBJECTIVES Tumour necrosis factor (TNF) alpha inhibitors (infliximab, etanercept, adalimumab) revolutionised the treatment of autoimmune diseases such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), Crohn's disease (CD) and plaque psoriasis. During these treatments, cutaneous adverse effects may occur like eczema, lupus, alopecia areata or psoriasis, which represents a paradoxical ad...