Introduction: During the last decade, advances in tissue engineering and stem cell-based tooth regeneration have provided realistic and attractive means of replacing lost or damaged teeth. The first adult stem cells isolated from dental tissues were dental pulp stem cells (DPSCs). When transplanted with hydroxyl apatite/tri calcium phosphate (HA/TCP) powder, they formed a dentin-like structure...

BACKGROUND: Pulp damage can lead to dentinogenesis impairment, irreversible pulpitis, or pulp necrosis. Despite being the most used endodontic procedure treat damaged pulp, root canal therapy only results in nonvital teeth which are prone fractures and secondary infection. Pulp-dentin regeneration has a potential regenerate structure similar normal pulp-dentin complex, be achieved by combining ...

This case report describes the treatment of two immature maxillary central incisors in a 7-year-old female patient. She suffered complicated crown fracture because of trauma, and the root formation was incomplete. White mineral trioxide aggregate (MTA) was selected as the pulp-capping material after cervical pulpotomy to preserve the pulp tissue vitality and achieve maturogenesis. Follow-up eva...

The purpose of this study was to determine the level of agreement between pediatric dentists and endodontists at a pulp therapy symposium conjointly sponsored by the American Association of Endodontists (AAE) and the American Academy of Pediatric Dentistry (AAPD) on November 2-3, 2007. Presymposium and postsymposium tests were administered, and respondent answers were compared between pediatric...

  Objective: In necrotic immature teeth, intra canal medicaments such as triple antibiotic paste (TAP) and calcium hydroxide (CH) are used for root canal disinfection and regeneration treatment. However, the effect of these medicaments on dental pulp fibroblasts has yet to be known. This study aimed to assess the cytotoxicity of CH and TAP against cultured human dental pulp fibroblasts (HDPFs) ...

The importance of inflammation has been underestimated in pulpal healing, and in the past, it has been considered only as an undesirable effect. Associated with moderate inflammation, necrosis includes pyroptosis, apoptosis, and nemosis. There are now evidences that inflammation is a prerequisite for pulp healing, with series of events ahead of regeneration. Immunocompetent cells are recruited ...

Dental pulp, which is surrounded by hard tissue (dentin and enamel), consists of pulp cells, odontoblasts, endothelial cells, neurons, immune system cells, and the extracellular matrix, and plays key roles in maintaining the function of healthy teeth [1]. Via the apical foramen of tooth, blood vessels supply nutrients to the tooth and remove waste products, and neural network warns for harmful ...

Medium composition for the callus induction, shoot multiplication in four Indian medicinal plants, Boerhaavia diffusa, Baliospermum axillare, Abutilon indicum and Nymphoides cristatum were standardized using Murashige and Skoog`s plant tissue culture medium as the basal medium. The protocol thus standardized was further evaluated replacing sucrose and vitamins with the fruit pulp of Borassus fl...