We present a critique and extension of the mean-field approach to the mechanical pulling transition in bound polymer systems. Our model is motivated by the theoretically and experimentally important examples of adsorbed polymers and double-stranded DNA. We focus on the case in which quenched disorder in the sequence of monomers is unimportant for the statistical mechanics, but we include exclud...

A double stranded DNA molecule under the stress of a pulling force acting on the strand terminals exhibits a partially denatured structure or can be completely unzipped depending the magnitude of the pulling force. A scaling argument for relationships amongst basic length scales is presented that takes into account the heterogeneity of the sequence. The result agrees with our numerical simulati...

Though biomechanically determined guidelines exist for lifting, existing recommendations for pushing and pulling were developed using a psychophysical approach. The current study aimed to establish objective hand force limits based on the results of a biomechanical assessment of the forces on the lumbar spine during occupational pushing and pulling activities. Sixty-two subjects performed pushi...

The mechanism of DNA compaction by dendrimers is key to the design of nanotechnologies that can deliver genetic material into cells. We present atomistic simulations, mesoscopic modeling and single-molecule pulling experiments describing DNA dendrimer interactions. All-atom molecular dynamics were used to characterize pulling-force-dependent interactions between DNA and generation-3 PAMAM amine...

Cylindrical thin-walled tubes due to construction and easy installation, high energy absorption capacity are used in the automotive industry as an impact energy absorber. However, the main weakness of cylindrical tubes is in the high initial peak load. Therefore, in this paper, to overcome this weakness, a buckling initiator is used at the top of the tube. This buckling initiator is a steel rod...

In typical force spectroscopy experiments, a small biomolecule is attached to a soft polymer linker that is pulled with a relatively large bead or cantilever. At constant force, the total extension stochastically changes between two (or more) values, indicating that the biomolecule undergoes transitions between two (or several) conformational states. In this paper, we consider the influence of ...

cylindrical thin-walled tubes due to construction and easy installation, high energy absorption capacity are used in the automotive industry as an impact energy absorber. however, the main weakness of cylindrical tubes is in the high initial peak load. therefore, in this paper, to overcome this weakness, a buckling initiator is used at the top of the tube. this buckling initiator is a steel rod...

Containing most of the L-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) on their tips, microvilli are believed to promote the initial arrest of neutrophils on endothelium. At the rolling stage following arrest, the lifetimes of the involved molecular bonds depend on the pulling force imposed by the shear stress of blood flow. With two different methods, electron microscopy and micropipe...