Peptic ulcer disease (PUD) occurs after a long-term Helicobacter pylori infection. However, the disease can develop earlier, and rare cases have been observed in children, suggesting that these H. pylori strains may be more virulent. We used suppressive subtractive hybridization for comparative genomics between H. pylori strains isolated from a 5-year-old child with duodenal ulcer and from a se...

The most common causes of peptic ulcer disease (PUD) are Helicobacter pylori infection and use of nonsteroidal anti-inflammatory drugs (NSAIDs). The test-and-treat strategy for detecting H. pylori is appropriate in situations where the risk of gastric cancer is low based on age younger than 55 years and the absence of alarm symptoms. Most other patients should undergo upper endoscopy to rule ou...

Peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) are not uncommon in elderly patients. Clinical presentations of these acid-related disorders may be atypical in the geriatric population. Older individuals are at increased risk for poor outcomes in complicated PUD and for development of GERD complications. Multiple risk factors (eg, Helicobacter pylori [HP], use of nonsteroi...

AIM It is controversial whether patients with non-ulcer dyspepsia (NUD) respond differently to Helicobacter pylori (H pylori) eradication treatment than those with peptic ulcer disease (PUD). To review the evidence for any difference in H pylori eradication rates between PUD and NUD patients. METHODS A literature search for full articles and meeting abstracts to July 2004 was conducted. We in...

UNLABELLED Helicobacter pylori and Epstein-Barr virus (EBV) infections are common worldwide. Although H. pylori infection is a major factor in gastroduodenal diseases, its role in association with EBV infection is unknown. OBJECTIVE To study the association of H. pylori infection and EBV DNA load in patients with gastroduodenal diseases. METHODS Biopsy samples were collected from 200 adult ...

Incompatibility of image descriptor and ranking is always neglected in image retrieval. In this paper, manifold learning and Gestalt psychology theory are involved to solve the incompatibility problem. A new holistic descriptor called Perceptual Uniform Descriptor (PUD) based on Gestalt psychology is proposed, which combines color and gradient direction to imitate the human visual uniformity. P...

BACKGROUND The plasticity region of Helicobacter pylori (H. pylori) is a large chromosomal segment containing strain-specific genes. The prevalence of the plasticity region genes of the H. pylori strains in China remains unknown. The aim of this study was to examine the status of these genes and to assess the relationship between the genes and the diseases caused by H. pylori infection. METHO...

Background In the last decades the incidence of peptic ulcer disease (PUD) has increased especially in the elderly. Haemorrhage is the most frequent PUD complication and its incidence is increasing in comparison to perforation and stenosis. Therapeutic endoscopy is considered the treatment of choice for bleeding ulcers, reducing the need for emergent surgical procedures to 10–20% of the cases.

Until the 1980s,peptic ulcer disease (PUD) was thought to be a chronic, incurable, relapsing disorder. This changed when Helicobacter pylori bacteria were identified as being responsible for the disease in most cases. This article outlines the epidemiology, pathophysiology, clinical manifestations and diagnosis of PUD, and briefly describes endoscopic therapies. A second article (p245) describe...