Previous data have demonstrated that administration of inflammatory cytokines or their inducers leads to altered basal ganglia function associated with reduced psychomotor speed. Decreased psychomotor speed, referred to clinically as psychomotor retardation, is a cardinal symptom of major depressive disorder (MDD) and has been associated with poor antidepressant treatment response. We therefore...

The onset of exercise facilitates an improvement in psychomotor performance until the second ventilatory threshold, after which performance is reduced. This inverted-U relationship appears valid for incremental and steady-state exercise, however, not for intermittent exercise. This study examined changes in psychomotor performance of team sport officials during a laboratory-based match simulati...

Psychomotor behaviors are governed by fine relationships between physical activity and cognitive functions. Disturbances in psychomotor development and performance are a hallmark of many mental illnesses and often appear as observable and measurable behaviors. Here, we describe a new method called an "equilibrist test," which can be used to quantify psychomotor learning and performance in Droso...

As has already been extensively commented in the article on antihistamines and the central nervous system, published in this same issue, all the classical antihistamines and, to a lesser extent, the more recent synthetic compounds are able to exert depressive action upon the central nervous system (CNS), causing drowsiness, lassitude, dizziness, incoordination, and increased reaction time. More...

Cytokines such as TNFα play an integral role in sleep/wake regulation and have recently been hypothesized to be involved in cognitive impairment due to sleep deprivation. We examined the effect of a guanine to adenine substitution at position 308 in the TNFα gene (TNFα G308A) on psychomotor vigilance performance impairment during total sleep deprivation. A total of 88 healthy women and men (age...

in two papers, one by R. Luft and the other by J. W. Conn and their respective colleagues. It is impossible in a short review to do justice to all these excellent papers. Suffice it to say that those who wish to learn of the most recent aspects of research in these fields of endocrinology cannot afford to ignore this volume. Since this is a yearly publication, many of the statements cannot refl...

Objectives To assess cognitive performance and psychomotor impairment in an HIV-positive cohort, well-suppressed on combination antiretroviral therapy (cART), in an Asian resource-limited setting. Methods Cross-sectional sociodemographic and cognitive data were collected in 329 HIV-positive and 510 HIV-negative participants. Cognitive performance was assessed using the International HIV Demen...

The influence of antipsychotic treatment on the neuropsychological and psychomotor performance of schizophrenic patients is still a subject of investigation. The present study was designed to evaluate the effects of atypical neuroleptics in comparison with a conventional dopamine antagonist neuroleptic (haloperidol) on several dimensions of psychomotor performance (visual perception, attention,...